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4025-75-6

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4025-75-6 Usage

Description

(4-Nitrophenyl)methanesulfonyl chloride, also known as 4-Nitrobenzylsulfonyl chloride, is an organic compound commonly utilized in chemical synthesis and pharmaceutical applications. It is characterized by its reactivity and ability to form various derivatives, making it a versatile compound in the field of chemistry.

Uses

Used in Pharmaceutical Industry:
(4-Nitrophenyl)methanesulfonyl chloride is used as a reagent for the preparation of HIV-1 Tat protein. This is achieved through native chemical ligation between a peptide thioester and a peptide containing (mercapto)leucine at the N-terminus, followed by desulfurization. This process plays a crucial role in the development of therapeutic strategies against HIV.

Check Digit Verification of cas no

The CAS Registry Mumber 4025-75-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4025-75:
(6*4)+(5*0)+(4*2)+(3*5)+(2*7)+(1*5)=66
66 % 10 = 6
So 4025-75-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO4S/c8-14(12,13)5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2

4025-75-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H25794)  4-Nitro-alpha-toluenesulfonyl chloride, 97%   

  • 4025-75-6

  • 1g

  • 501.0CNY

  • Detail
  • Alfa Aesar

  • (H25794)  4-Nitro-alpha-toluenesulfonyl chloride, 97%   

  • 4025-75-6

  • 5g

  • 1524.0CNY

  • Detail
  • Alfa Aesar

  • (H25794)  4-Nitro-alpha-toluenesulfonyl chloride, 97%   

  • 4025-75-6

  • 25g

  • 4953.0CNY

  • Detail

4025-75-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-Nitrophenyl)methanesulfonyl chloride

1.2 Other means of identification

Product number -
Other names 4-nitrobenzylsulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4025-75-6 SDS

4025-75-6Relevant articles and documents

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγInverse Agonist for Treatment of Castration-Resistant Prostate Cancer

Zhang, Yan,Wu, Xishan,Xue, Xiaoqian,Li, Chenchang,Wang, Junjian,Wang, Rui,Zhang, Cheng,Wang, Chao,Shi, Yudan,Zou, Lingjiao,Li, Qiu,Huang, Zenghong,Hao, Xiaojuan,Loomes, Kerry,Wu, Donghai,Chen, Hong-Wu,Xu, Jinxin,Xu, Yong

, p. 4716 - 4730 (2019/05/08)

We report the design, optimization, and biological evaluation of nuclear receptor RORγinverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50/su

Preparation method of almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine

-

Paragraph 0043-0044; 0050-0051; 0057-0058; 0064-0065; 0071, (2018/09/12)

The invention discloses a preparation method of an almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine. The main steps comprise: 1) preparing a Vilsmeier reagent by using BTC andDMF, and carrying out a sulfonylation reaction on p-nitr

Clean and economic synthesis of alkanesulfonyl chlorides from S-alkyl isothiourea salts via bleach oxidative chlorosulfonation

Yang, Zhanhui,Zhou, Bingnan,Xu, Jiaxi

, p. 225 - 229 (2014/03/21)

A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.

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