402616-23-3 Usage
Description
FTY720 (R)-Phosphate, also known as Fingolimod Phosphate, is a synthetic compound derived from myriocin, a fungal metabolite. It is an immunomodulatory agent that acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors, playing a crucial role in the regulation of lymphocyte trafficking and immune response. FTY720 (R)-Phosphate has shown potential as a new target in the treatment of autoimmune diseases and has been approved for the treatment of multiple sclerosis.
Uses
Used in Pharmaceutical Industry:
FTY720 (R)-Phosphate is used as an immunomodulatory agent for the treatment of autoimmune diseases, particularly multiple sclerosis. It modulates the immune system by sequestering lymphocytes in the lymph nodes, reducing their migration to the central nervous system, and thereby mitigating the inflammatory process associated with the disease.
Used in Autoimmune Disease Treatment:
FTY720 (R)-Phosphate is used as a therapeutic agent for the treatment of autoimmune diseases. It targets the S1P receptors, which play a significant role in immune cell trafficking and function. By acting as an agonist at these receptors, FTY720 (R)-Phosphate can help regulate the immune response and reduce the severity of autoimmune conditions.
Used in Sphingolipid Homeostasis Research:
FTY720 (R)-Phosphate is used as a research tool in the study of sphingolipid homeostasis. As an intermediate in the sphingolipid pathway, it helps researchers understand the role of S1P receptors in various biological processes and their potential as therapeutic targets for immune system modulation.
Used in Drug Development:
FTY720 (R)-Phosphate serves as a starting point for the development of new drugs targeting the S1P receptors. Its unique mechanism of action and potential applications in autoimmune disease treatment make it an attractive candidate for further research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 402616-23-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,2,6,1 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 402616-23:
(8*4)+(7*0)+(6*2)+(5*6)+(4*1)+(3*6)+(2*2)+(1*3)=103
103 % 10 = 3
So 402616-23-3 is a valid CAS Registry Number.
402616-23-3Relevant articles and documents
Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720
Lu, Xuequan,Bittman, Robert
, p. 825 - 827 (2007/10/03)
The enantiomers of FTY720-phosphate (3) were synthesized via 2-methylene-4-(4-octylphenyl)butan-1-ol (7), 2,3-epoxy alcohol 8, and Δ2-oxazoline 10. These compounds have potential use in the treatment of autoimmune diseases and prevention of kid
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer
Albert, Rainer,Hinterding, Klaus,Brinkmann, Volker,Guerini, Danilo,Müller-Hartwieg, Constanze,Knecht, Helmut,Simeon, Corinne,Streiff, Markus,Wagner, Trixie,Weizenbach, Karl,Zécri, Frédéric,Zollinger, Markus,Cooke, Nigel,Francotte, Eric
, p. 5373 - 5377 (2007/10/03)
In vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde derivatization protocol especially elaborated for phosphates of 1. Starting from the prochiral amino alcohol 1, racemic and enantiomerically pure phosphates of 1 were synthesized. Pure enantiomers were obtained after purification of a partially protected key intermediate on an enantioselective support. The absolute stereochemistry was determined by X-ray diffraction.
