4027-39-8Relevant articles and documents
Isolation of intermediates in the rearrangement of 4-cyano-4,5-dihydroazepines to furo[2,3-b]pyridine derivatives
Gregory,Bullock,Chen
, p. 4061 - 4065 (1977)
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One-pot synthesis of 3,4-dihydropyridin-2-ones via tandem reaction of Blaise reaction intermediate and acrylic ester
Meng, Tuanjie,Liu, Lantao,Jia, Huiyi,Ren, Lifeng,Feng, Cuilan,Wang, Xiaojuan,Zhao, Wenxian
, p. 47 - 50 (2016)
An efficient method for the synthesis 3,4-dihydropyridin-2-ones has been developed via tandem one-pot Michael-type addition and cyclization of the Blaise reaction intermediate and acrylic ester. A series of readily available nitriles, bromoacetic esters and acrylic esters have been employed to examine the scope of substrates for this method.
Synthesis of 2,3-disubstituted 4-pyridone from a β-aminocarboxylate derivative and acetoacetate
Sobczak, Adam,Antkowiak, Wieslaw Z.
, p. 2993 - 3001 (2007/10/03)
The reaction of diethyl aminomethylenemalonate with ethyl acetoacetate proceeded, when catalyzed by anhydrous hydrogen chloride, toward a respectively substituted α- instead of γ-pyridone derivative formation, contrary to the literature report. Additionally, it was found that the amine used as a starting component in this reaction showed a great tendency to autocondensation under the influence of anhydrous hydrogen chloride to yield 5-ethoxycarbonyl-2- pyridone. The most convenient method to prepare 4-pyridone 2,3-disubstituted derivative appeared to be a three-step synthesis, starting from a chain enamine formation, which was subjected to cyclization, followed by oxidation of the last intermediate. The usefulness of the stepwise synthesis was demonstrated on the 3-ethoxycarbonyl-2-methyl-4-pyridone preparation as an example. Copyright Taylor & Francis, Inc.
