402848-76-4

Basic information

• Product Name: Nitazoxanide Impurity
• Synonyms: Nitazoxanide Impurity;2-Acetoxy-N-(2-thiazolyl)benzamide;1H-1,2,3-Triazole-5-carboxylic acid, 4-cyano-, methyl ester;2-acetoxybenzoyl-N-(thiazol-2-yl)amide
• CAS NO: 402848-76-4
• Molecular Formula: C₁₂H₁₀N₂O₃S
• Molecular Weight: 262.28
• Mol File: 402848-76-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140-142 °C
• Appearance: /
• Density: 1.390±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.10±0.50(Predicted)
• CAS DataBase Reference: Nitazoxanide Impurity(CAS DataBase Reference)
• NIST Chemistry Reference: Nitazoxanide Impurity(402848-76-4)
• EPA Substance Registry System: Nitazoxanide Impurity(402848-76-4)

Safety Data

• Hazardous Substances Data: 402848-76-4(Hazardous Substances Data)

Usage

Uses

2-Acetoxy-N-(2-thiazolyl)-benzamide is used in the synthesis of thiazolides as novel antiviral agents. Used in the inhibition of hepatitis C virus replication. Nitazoxanide Impurity

Upstream product

• 96-50-4 2-thiazolylamine 
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Downstream Products

• 130234-70-7 RM₄₈₅₇ 

Relevant articles and documents

Synthesis and antiplasmodial assessment of nitazoxanide and analogs as new antimalarial candidates

During the last years, the progression to control malaria disease seems to be slowed and WHO (World Health Organization) reported a modeling analysis with the prediction of the increase in malaria morbidity and mortality in sub-Saharan Africa during the COVID-19 pandemic. A rapid way to the discovery of new drugs could be carried out by performing investigations to identify drugs based on repurposing of “old” drugs. The 5-nitrothiazole drug, Nitazoxanide was shown to be active against intestinal protozoa, human helminths, anaerobic bacteria, viruses, etc. In this work, Nitazoxanide and analogs were prepared using two methodologies and evaluated against P. falciparum 3D7. A bithiazole analog, showed attractive inhibitory activity with an EC50 value of 5.9 μM, low propensity to show toxic effect against HepG2 cells at 25 μM, and no cross-resistance with standard antimalarials.