40288-35-5

Basic information

• Product Name: 1-p-tolyl-3-benzylthiocarbamide
• Synonyms: 1-p-tolyl-3-benzylthiocarbamide
• CAS NO: 40288-35-5
• Molecular Weight: 256.371
• Mol File: 40288-35-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-p-tolyl-3-benzylthiocarbamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-p-tolyl-3-benzylthiocarbamide(40288-35-5)
• EPA Substance Registry System: 1-p-tolyl-3-benzylthiocarbamide(40288-35-5)

Safety Data

• Hazardous Substances Data: 40288-35-5(Hazardous Substances Data)

Usage

Type

Chemical compound

Common uses

Research (thyroid peroxidase inhibitor)
Medicine (treatment for hyperthyroidism)

Mechanism of action

Inhibits the synthesis of thyroid hormone

Effects

Reduces hormone levels produced by the thyroid gland

Benefits in hyperthyroidism treatment

Manages symptoms (rapid heartbeat, weight loss, and sweating)

Additional uses

Preparing animals for thyroidectomy surgery
Studied for potential antiviral and anti-cancer properties

Precaution

Should be used under the supervision of a healthcare professional due to potential side effects and interactions with other medications.

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 100-46-9 benzylamine 
• 621-01-2 1,3-di-p-tolylthiocarbamide 
• 112664-49-0 3-tert-butylimino-4-p-tolyl-5-p-tolylimino-1,2,4-dithiazolidine 
• 622-78-6 Benzyl isothiocyanate 
• 106-49-0 p-toluidine 

Downstream Products

• 69583-41-1 3-benzyl-2-p-tolylimino-thiazolidin-4-one 
• 76746-69-5 C₁₆H₁₈N₄S*ClH 
• 76746-59-3 3-amino-5-benzylimino-4-p-tolyl-4,5-dihydro-1,2,4-thiadiazole 
• 55424-90-3 benzyl-(p-methylphenyl)carbodiimide 
• 76746-76-4 C₁₆H₁₈N₄S*2ClH 

Relevant articles and documents

Micelle-Enabled One-Pot Guanidine Synthesis in Water Directly from Isothiocyanate using Hypervalent Iodine(III) Reagents under Mild Conditions

In this work, we developed a one-pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as a desulfurizing agent under micellar conditions in water. Our optimization study revealed that the use of 1 % TPGS-750-M as a surfactant with NaOH as an additive base at room temperature can convert a variety of isothiocyanates and amines into corresponding guanidines in excellent yields (69–95 %). This synthetic process in water can be applied to prepare guanidine at gram-scale quantity. Our aqueous micellar medium also demonstrated high reusability as the reaction can be performed for several cycles without losing its efficiency. The reaction is metal-free, utilizes water as solvent and practical (room temperature and open flask).

Synthesis and characterisation of [(en)2Co]3+ complexes coordinated by substituted thiourea ligands

Substituted thiourea ligands bind in a bidentate manner forming a four-membered ring through the sulfur atom and a deprotonated thiourea nitrogen atom when reacted with [(en)2Co(OSO2CF3)2]+ in tetramethylene sulfone. Reaction of unsymmetrical ligands results in the formation of coordination isomers, some of which can be separated by column chromatography using Sephadex SPC-25. Coordination isomers are easily distinguishable based on visible and 1H NMR spectroscopy . Twelve para-substituted and one meta-substituted ligands were studied: N,N′-dibenzylthiourea (1a); N-(R)phenyl-N′-benzylthiourea R≤H (2a), NO2 (2b), CH3 (2c); N-(R)phenyl-N′-(R′)phenylthiourea R, R′: H, H (3a), H, CH3 (3b), OCH3, NO2 (3c), CH3, NO2 (3d); N-methyl-N′-(R)phenylthiourea R≤H (4a), CH3 (4b), OCH3 (4c), NO2 (4d), 3-CH3 (4e). The solid state structure (X-ray) of one isomer of Co-4a as its perchlorate salt confirms the coordination mode suggested by 1H NMR spectroscopy and shows that the Co-N bond trans to the coordinated thiourea sulfur induces a structural trans effect of 0.019A.

Synthesis of 3-t-Butylimino-4-aryl/alkyl-5-aryl/alkylimino-1,2,4-dithiazolidines and their De-t-butylation into related 3-Imino-1,2,4-dithiazolidines

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