40290-56-0

Basic information

• Product Name: Z-LEU-SER-OME
• Synonyms: CARBOBENZYLOXY-L-LEUCYL-L-SERINE METHYL ESTER;Z-LEU-SER-OME
• CAS NO: 40290-56-0
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.41
• Mol File: 40290-56-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-LEU-SER-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LEU-SER-OME(40290-56-0)
• EPA Substance Registry System: Z-LEU-SER-OME(40290-56-0)

Safety Data

• Hazardous Substances Data: 40290-56-0(Hazardous Substances Data)

Usage

General Description

Z-LEU-SER-OME is a synthetic peptide that contains the amino acids leucine and serine. It is designed to mimic the structure of natural peptides found in the body and has been shown to have potential therapeutic effects in areas such as inflammation and immune response modulation. The Z-LEU-SER-OME peptide has been studied for its ability to inhibit the activity of certain enzymes involved in the inflammatory process, as well as to promote the production of anti-inflammatory molecules. This chemical compound is being investigated for its potential use in the development of novel treatments for conditions such as autoimmune diseases and inflammatory disorders.

Upstream product

• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 2788-84-3 (S)-serine methyl ester 
• 2018-66-8 Z-Leu-OH 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 148854-04-0 (C₈H₇O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 

Downstream Products

• 212612-28-7 Z-Leu-Ser-OH 
• 1384457-99-1 N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester 
• 1384458-02-9 (Z)-N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydro-5-(phenyl)norvaline methyl ester 
• 1384458-01-8 N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydrovaline methyl ester 
• 1384458-00-7 (Z)-N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydroleucine methyl ester 
• 1384457-98-0 N-(N-benzyloxycarbonyl-L-leucyl)-2-(methoxy)glycine methyl ester 
• 155225-21-1 (2R,5S)-2-hydroxymethyl-5-iso-butylpiperazine 

Relevant articles and documents

Tripeptide analogues of MG132 as protease inhibitors

The 26S proteasome and calpain are linked to a number of important human diseases. Here, we report a series of analogues of the prototypical tripeptide aldehyde inhibitor MG132 that show a unique combination of high activity and selectivity for calpains over proteasome. Tripeptide aldehydes (1–3) with an aromatic P3 substituent show enhanced activity and selectivity against ovine calpain 2 relative to chymotrypsin-like activity of proteasome. Docking studies reveal the key contacts between inhibitors and calpain to confirm the importance of the S3 pocket with respect to selectivity between calpains 1 and 2 and the proteasome.

Chiral Ligands Containing Heteroatoms. 11. Optically Active 2-Hydroxymethyl Piperazines as Catalyst in the Enantioselective Addition of Diethylzinc to Benzaldehyde

Starting from enantiomerically pure serine, a series of (2R,5S) and (2S,5S)-2-hydroxymethyl-5-alkyl piperazines 1-5 were prepared in good yields without any racemization.The use of these compounds as chiral catalysts for the enantioselective addition of d