402958-23-0Relevant articles and documents
Synthesis and evaluation of tripeptidyl α-ketoamides as human rhinovirus 3C protease inhibitors
Chen, Shu-Hui,Lamar, Jason,Victor, Frantz,Snyder, Nancy,Johnson, Robert,Heinz, Beverly A.,Wakulchik, Mark,Wang, Q. May
, p. 3531 - 3536 (2007/10/03)
We describe herein the synthesis and biological evaluation of a series of tripeptidyl α-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.