403-32-7

Basic information

• Product Name: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE
• Synonyms: 4-fluoro-alpha-oxo-benzeneacetaldehyd;4-fluoro-alpha-oxobenzeneacetaldehyde;4-FLUOROPHENYLGLYOXAL;(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE;4-Fluoro-α-oxo-benzeneacetaldehyde;Benzeneacetaldehyde, 4-fluoro-.alpha.-oxo-;(p-Fluorophenyl)glyoxal;NSC 402742
• CAS NO: 403-32-7
• Molecular Formula: C₈H₅FO₂
• Molecular Weight: 170.14
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 403-32-7.mol
• Article Data: 55

Chemical Properties

• Melting Point: 84-88℃
• Boiling Point: 214.5°Cat760mmHg
• Flash Point: 80.4°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.155mmHg at 25°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(403-32-7)
• EPA Substance Registry System: (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE(403-32-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: CY1440000
• Hazardous Substances Data: 403-32-7(Hazardous Substances Data)

Usage

Description

(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE, also known as 4-Fluoro-α-oxo-benzeneacetaldehyde (CAS# 403-32-7), is a white solid compound with significant utility in the field of organic synthesis. Its unique chemical structure, featuring a fluoro-substituted phenyl group and an oxo-acetaldehyde moiety, makes it a versatile building block for the creation of various complex organic molecules.

Uses

Used in Pharmaceutical Industry:
(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE is used as a synthetic intermediate for the development of novel pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential applications in treating various diseases and medical conditions.
Used in Chemical Research:
In the field of chemical research, (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE serves as a valuable compound for studying the reactivity and properties of fluorinated aromatic systems. Its use in research can lead to a better understanding of the underlying chemical mechanisms and the development of new synthetic methodologies.
Used in Material Science:
(4-FLUORO-PHENYL)-OXO-ACETALDEHYDE is used as a precursor in the synthesis of advanced materials, such as fluorinated polymers and coatings. These materials can exhibit enhanced properties, such as increased chemical stability, improved thermal resistance, and reduced friction, making them suitable for various industrial applications.
Used in Agrochemical Industry:
In the agrochemical industry, (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE is used as a key intermediate in the synthesis of new pesticides and agrochemicals. Its incorporation into these compounds can lead to improved efficacy, selectivity, and reduced environmental impact.
Overall, (4-FLUORO-PHENYL)-OXO-ACETALDEHYDE is a versatile and valuable compound with a wide range of applications across various industries, including pharmaceuticals, chemical research, material science, and agrochemicals. Its unique chemical properties and reactivity make it an essential component in the development of new and innovative products.

InChI:InChI=1/C8H5FO2.H2O/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-5H;1H2

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 462-06-6 fluorobenzene 
• 403-31-6 4-fluoro-2-hydroxy-acetophenone 
• 405-99-2 para-fluorostyrene 

Downstream Products

• 65709-33-3 (RS)-2-(4-fluorophenyl)piperazine 
• 1187829-39-5 (4‐fluorophenyl)[4‐(4‐fluorophenyl)‐1H‐imidazol‐2‐yl]methanone 
• 1389334-36-4 C₁₉H₁₉FN₂O₃ 
• 1384521-95-2 diethyl 4-(4-fluorobenzoyl)isoxazole-3,5-dicarboxylate 
• 1232039-18-7 C₁₃H₈BrFN₂O 
• 1227678-12-7 ethyl 6-(4-fluorophenyl)-3-methylpyridazine-4-carboxylate 
• 1227678-20-7 tert-butyl 6-(4-fluorophenyl)-3-methylpyridazine-4-carboxylate 
• 1314877-58-1 C₁₂H₇FN₂O₃S 
• 1227411-44-0 3-(2-(4-fluorophenyl)-1-hydroxy-2-oxoethyl)-3-methylindolin-2-one 
• 71347-48-3 5-(4-fluorophenyl)-3-(methylthio)-1,2,4-triazine 
• 1217509-43-7 5-(2-amino-4-(4-fluorophenyl)thiazol-5-yl)-6-hydroxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present application relates to a substituted aryl compound or a pharmaceutically acceptable salt, a stereoisomer, a polymorph, a solvate, a N-oxide, an isotope-labeled compound, a metabolite or a prodrug thereof, and a preparation method therefor and use thereof, also relates to a pharmaceutical composition containing the compound and a therapeutic use thereof. The compound or a pharmaceutical composition thereof can inhibit the activity of adenosine A2a receptor, and can be used for treating or preventing a disease related to adenosine A2a receptor, especially for treating a tumor.

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

1-phenyl-2-phenylaminoethyl ketone derivative and medical application

The invention belongs to the field of pharmaceutical chemicals, and relates to a micromolecular inhibitor of polymyxin drug-resistant protein MCR-1 and application thereof. The invention relates to acompound shown as a formula I, a pharmaceutically accept