40337-66-4

Basic information

• Product Name: 4-(3-BROMO-PROPYL)-PYRIDINE
• Synonyms: 4-(3-BROMO-PROPYL)-PYRIDINE
• CAS NO: 40337-66-4
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Mol File: 40337-66-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 248.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.378±0.06 g/cm3(Predicted)
• PKA: 5.89±0.10(Predicted)
• CAS DataBase Reference: 4-(3-BROMO-PROPYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-BROMO-PROPYL)-PYRIDINE(40337-66-4)
• EPA Substance Registry System: 4-(3-BROMO-PROPYL)-PYRIDINE(40337-66-4)

Safety Data

• Hazardous Substances Data: 40337-66-4(Hazardous Substances Data)

Upstream product

• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 64262-18-6 4-(3-bromopropyl)pyridine hydrobromide 

Downstream Products

• 1201042-28-5 (R)-3-((S)-2-phenyl-2-piperidin-1-yl-propionyloxy)-1-(3-pyridin-4-yI-propyl)-1-azonia-bicyclo[2.2.2]octane bromide 
• 1426824-02-3 C₂₄H₂₂N₂O₂S₇ 
• 116578-57-5 N-[3-(pyrid-4-yl)propyl]-N-methyl-amine 
• 118892-71-0 cis-4-(3-phosphonoprop-1-yl)piperidine-2-carboxylic acid 

Relevant articles and documents

Electrochemical driven water oxidation by molecular catalysts in situ polymerized on the surface of graphite carbon electrode

A simple strategy to immobilize highly efficient ruthenium based molecular water-oxidation catalysts on the basal-plane pyrolytic graphite electrode (BPG) by polymerization has been demonstrated. The electrode 1@BPG has obtained a high initial turnover frequency (TOF) of 10.47 s-1 at ～700 mV overpotential, and a high turnover number (TON) up to 31600 in 1 h electrolysis.

1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention provides named compounds of formula (I), pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions and their use in therapy.

Synthesis and Pharmacology of a Series of 3- and 4-(Phosphonoalkyl)pyridine- and piperidine-2-carboxylic Acids. Potent N-Methyl-D-aspartate Receptor Antagonists

We recently prepred a series of 3- and 4-(phosphonoalkyl)pyridine- and piperidine-2-carboxylic acids as antagonists of neurotransmission at N-methyl-D-aspartate (NMDA) preferring receptors.NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsants, in the treatment of neurodegenerative disorders such as Alzheimer's disease and in the prevention of neuronal damage that occurs during cerebral ischemia.The compounds prepared were evaluated for their ability to displace CPP binding (an assay shown to be selective for compounds that bind at the NMDA receptor) and for their ability to block NMDA-induced lethality in mice (an assay that is also specific for competitive and noncompetitive NMDA antagonists).Two of the compounds, cis-4-(phosphonomethyl)piperidine-2-carboxylic acid (11a) and cis-4-(3-phosphonoprop-1-yl)piperidine-2-carboxylic acid (11c) proved to be potent NMDA antagonists. 11a and 11c displaced CPP binding with IC 50's of 95 and 120 nM, respectively, and both protected mice from NMDA-induced lethality, with MEDs (minimum effective dose, the dose at which three of the five animals tested survived) of 10 and 40 mg/kg ip, respectively.The rest of the compounds prepared were weakly active or inactive in these assays.The pattern of activity observed for this series parallels that observed for the acyclic series of ω-phosphono-α-amino acids, where AP5 and AP7 possessed NMDA antagonist activity while AP6 and AP8 were inactive.Reduction of conformational mobility by incorporation of the piperidine ring led to enhanced potency relative to the acyclic analogues.