40345-42-4Relevant articles and documents
(m.n)-Homorubins: Syntheses and structures
Pfeiffer, William P.,Lightner, David A.
, p. 1777 - 1801 (2015/02/19)
Five new homorubin analogs of bilirubin with their two dipyrrinone components conjoined to (CH2)2, (CH2)3, and (CH2)4 units were synthesized with propionic acid chains shortened to acetic and elongated to butyric, and examined by spectroscopy and molecular mechanics computations for an ability to form conformation-determining hydrogen bonds. With m designating the number of conjoining CH2 units and n indicating the number of CH2 units of the alkanoic acid chains of ( m.n)-homorubins, (2.1)-, (3.2)-, (4.2)-, and (4.3)-homorubins were prepared and compared with previously synthesized (2.2) and (2.3), which adopt intramolecularly hydrogen-bonded conformations in CHCl3.
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
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Page 13, (2010/02/10)
The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.
Synthesis of some novel porphyrins
Singh, Vandana,Baqi, Abdul
, p. 908 - 910 (2007/10/03)
2,3,6,7-Tetra(2-methoxycarbonylethyl)-1,4,5,8-tetramethyiporphin [coproporphyrin II, tetramethyl ester] (9) and 2,3-di(2-methoxycarbonylethyl)-6,7-dimethoxycarbonylmethyl-1,4,5, 8-tetramethylporphin] a new synthetic coproporphyrin] (10) were synthesized by condensing 3,3′-dimethoxycarbonylethyl)-4,4′-dimethyl-2,2′ -dipyrrylmethane-5,5′-dicarboxylic acid (5) with 3,3′ -di(2-ethoxycarbonylethyl)-5,5′-diformyl-4,4′-dimethyl-2, 2′-dipyrrylmethane (6) and 3,3′-dicarboxymethyl-4,4′ -dimethyl-2,2′-dipyrrylmethane-5,5′-dicarboxylic acid (8) with 6, respectively. Tetra-substituted pyrroles for synthesizing appropriate dipyrrylmethanes were synthesized in good yields by extension and modification of Knorr synthesis.
