40360-44-9

Basic information

• Product Name: 3,5,6-Trichloropicolinic acid
• Synonyms: 3,5,6-Trichloropicolinic acid;3,5,6-Trichloro-2-picolinic Acid;2-Pyridinecarboxylic acid, 3,5,6-trichloro-;3,5,6-Trichloro-2-pyridinecarboxylic Acid;3,5,6-Trichloro-2-pyridinyl Acetic Acid
• CAS NO: 40360-44-9
• Molecular Formula: C6H2Cl3NO2
• Molecular Weight: 226.446
• EINECS: -0
• Product Categories: Aromatics;Heterocycles
• Mol File: 40360-44-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 342.6 °C at 760 mmHg
• Flash Point: 161 °C
• Appearance: /
• Density: 1.728 g/cm³
• Vapor Pressure: 2.87E-05mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5,6-Trichloropicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,6-Trichloropicolinic acid(40360-44-9)
• EPA Substance Registry System: 3,5,6-Trichloropicolinic acid(40360-44-9)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 40360-44-9(Hazardous Substances Data)

Usage

Chemical Properties

Light brown solid

InChI:InChI=1/C6H2Cl3NO2/c7-2-1-3(8)5(9)10-4(2)6(11)12/h1H,(H,11,12)

Upstream product

• 17824-83-8 3,4,5,6-tetrachloropicolinonitrile 
• 2402-79-1 2,3,5,6-tetrachloropyridine 
• 10469-09-7 3,4,5,6-tetrachloropyridinecarboxylic acid 
• 496849-77-5 4,5,6-trichloropicolinic acid 
• 32889-74-0 3,5,6-trichloro-4-hydrazinopicolinic acid 
• 406676-23-1 2,3,5-trichloro-4-iodopyridine 
• 16063-70-0 2,3,5-trichloropyridine 
• 124-38-9 carbon dioxide 
• 78121-76-3 2,3,5-trichloro-6-iodopyridine 

Relevant articles and documents

Preparative method for carboxylic acids

A preparative method for carboxylic acids is disclosed in the present invention. The method is characterized in that: compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), as represented by the following reaction scheme: wherein R1 is aryl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, thiadiazolyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl and hydrogen; R2 is alkoxycarbonyl, alkylaminocarbonyl, aminocarbonyl, alkylthiolcarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, aldehyde, carboxyl, nitro, alkyl and hydrogen; R3 is alkoxycarbonyl, alkyl amido carbonyl, aminocarbonyl, cyano, sulfonyl, sulfinyl, carbonyl, carboxyl and nitro. The present invention has the following main benefits: cheap and readily available starting materials, safe processes, high yield, good quality, which facilitates industrial production.

NOVEL COMPOSITIONS AND METHODS OF USE

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

Preparation of 3,5,6-trichloropicolinic acid

3,5,6-Trichloropicolinic acid is prepared in a process which comprises A. reacting by contacting tetrachloropicolinic acid, hydrazine and an alkali reaction medium in water; B. reacting by contacting the thus formed 3,5,6-trichloro-4-hydrazinopicolinic acid intermediate with an alkali metal hydroxide and an alkaline hypochlorite solution; and C. acidifying the reaction mixture with a mineral acid and recovering the desired 3,5,6-trichloropicolinic acid product.