403605-43-6

Basic information

• Product Name: tert-butyl quinoline-6-carboxylate
• Synonyms: tert-butyl quinoline-6-carboxylate;quinoline-6-carboxylic acid tert-butyl ester
• CAS NO: 403605-43-6
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.2744
• Mol File: 403605-43-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl quinoline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl quinoline-6-carboxylate(403605-43-6)
• EPA Substance Registry System: tert-butyl quinoline-6-carboxylate(403605-43-6)

Safety Data

• Hazardous Substances Data: 403605-43-6(Hazardous Substances Data)

Upstream product

• 863492-31-3 tert-butyl quinoline-6-carboxylate N-oxide 
• 10349-57-2 Quinoline-6-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 

Relevant articles and documents

Safe and practical large-scale synthesis of 2-aminoquinoline-6-carboxylic acid benzyl ester

An efficient three-step sequence has been developed for the synthesis of 2-aminoquinoline-6-carboxylic acid benzyl ester starting from commercially available 6-quinolinecarboxylic acid. The process features a novel and exceptionally mild conversion of a q

Highly Chemoselective Deoxygenation of N-Heterocyclic N-Oxides Using Hantzsch Esters as Mild Reducing Agents

Herein, we disclose a highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant. Despite the feasibility of catalyst-free conditions, most of these deoxygenations can be completed within a few minutes using only a tiny amount of a catalyst. This technology also allows for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompasses a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups, and halogens, which provide access to the corresponding deoxygenated N-heterocycles in good to excellent yields (an average of an 86.8% yield for a total of 45 examples).

SUBSTITUTED QUINOLINE COMPOUNDS

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.