403816-18-2

Basic information

• Product Name: 3,4-diphenyl-1-(3-phenylpropyl)-1H-pyrrole-2,5-dione
• Synonyms: 3,4-diphenyl-1-(3-phenylpropyl)-1H-pyrrole-2,5-dione
• CAS NO: 403816-18-2
• Molecular Weight: 367.447
• Mol File: 403816-18-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,4-diphenyl-1-(3-phenylpropyl)-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diphenyl-1-(3-phenylpropyl)-1H-pyrrole-2,5-dione(403816-18-2)
• EPA Substance Registry System: 3,4-diphenyl-1-(3-phenylpropyl)-1H-pyrrole-2,5-dione(403816-18-2)

Safety Data

• Hazardous Substances Data: 403816-18-2(Hazardous Substances Data)

Upstream product

• 31295-36-0 diphenylmaleimide 
• 103-82-2 phenylacetic acid 
• 4808-48-4 2,3-diphenylmaleic anhydride 

Downstream Products

• 4808-48-4 2,3-diphenylmaleic anhydride 
• 30684-05-0 3-phenylpropylamine hydrochloride 

Relevant articles and documents

Application of maleimide compound as chitin synthase inhibitor

The invention discloses an application of a maleimide compound as shown in a formula I. In the formula I, R0 is phenyl, benzyl, phenethyl, phenylpropyl, p-fluorophenyl, p-chlorophenyl, p-bromophenyl,p-methoxyphenyl, p-methylphenyl or p-hydroxyphenyl, R1 is hydrogen, methyl, phenyl or chlorine; and R2 is hydrogen, methyl, phenyl or chlorine. The provided maleimide compound has a good inhibition effect on chitin synthase.

A method for the production of primary amines

The invention relates to the field of chemical industry and particularly relates to a method for preparing primary amine by using the raw materials including halogenated hydrocarbon (or hydrocarbon alcohol sulfonate) and ammonia water (or formamide). The method comprises the following three steps: (1) imidization: 3,4-diarylfuran-2,5-diketone (I) reacts with ammonia (or formamide) and the like to obtain 3,4-diaryl-1H-pyrrole-2,5-diketone (II); (2) N-hydrocarbylation: 3,4-diaryl-1H-pyrrole-2,5-diketone (II) generates an N-hydrocarbylation reaction with halogenated hydrocarbon (or hydrocarbon alcohol sulfonate) in the presence of alkali to obtain N-hydrocarbyl-3,4-diaryl-1H-pyrrole-2,5-diketone (III); and (3) hydrolysis: N-hydrocarbyl-3,4-diaryl-1H-pyrrole-2,5-diketone (III) is subjected to alkali hydrolysis to obtain primary amine and the generated 2,3-diaryl maleate is subjected to acid treatment and automatic ring closing to form 3,4-diaryl furan-2,5-diketone (I) which is subjected to imidization and directly applied to the N-hydrocarbylation reaction. The method provided by the invention has the characteristics that the 3,4-diaryl furan-2,5-diketone can be circularly used at a high recovery rate, the molar ratio of the raw materials is low, and the yield of the product primary amine is high.