403848-01-1

Basic information

• Product Name: 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)
• Synonyms: 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S);4H-THIENO[2,3-B]THIOPYRAN-4-AMINE
• CAS NO: 403848-01-1
• Molecular Formula: C7H7NS2
• Molecular Weight: 169.271
• Mol File: 403848-01-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.628°C at 760 mmHg
• Flash Point: 199.722°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.585
• Solubility: Methanol; Ethyl Acetate; DCM
• CAS DataBase Reference: 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)(403848-01-1)
• EPA Substance Registry System: 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)(403848-01-1)

Safety Data

• Hazardous Substances Data: 403848-01-1(Hazardous Substances Data)

Usage

Description

4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S) is a complex organic compound with a unique molecular structure. It is characterized by its thieno[2,3-b]thiopyran core, which is fused with a nitrogen-containing amine group. The molecule also features an ethyl group attached to the nitrogen and a methyl group at the 6-position. The 7,7-dioxide functional group adds further complexity to its structure. 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S) is a chiral molecule, with the (4S,6S) configuration indicating the specific arrangement of its atoms in three-dimensional space.

Uses

Used in Pharmaceutical Industry:
4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Synthesis of Desaminosulfonyl Dorzolamide:
In the pharmaceutical industry, this compound is specifically used as an intermediate in the synthesis of 2-Desaminosulfonyl 3-Aminosulfonyl Dorzolamide (D288235). This synthetic compound is derived from (4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-Dioxide (T344510), which is an analog of the topically-active carbonic anhydrase inhibitor MK-507, commonly known as Dorzolamide (D535100). The development of such analogs can lead to improved treatments for conditions like glaucoma and other eye disorders.
Used in Research and Development:
Due to its unique structure and chiral configuration, 4H-Thieno[2,3-b]thiopyran-4-amine,N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S) can also be used in research and development for exploring new chemical reactions, understanding the properties of similar compounds, and potentially discovering new applications in various industries, including materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C10H15NO2S2/c1-3-11-9-6-7(2)15(12,13)10-8(9)4-5-14-10/h4-5,7,9,11H,3,6H2,1-2H3/t7-,9-/m0/s1

Upstream product

• 147086-83-7 4-(N-acetamido)-5,6-dihydro-6-methyl-4H-thien-(2,3-b)-thiopyran-7,7-dioxide 

Relevant articles and documents

Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates

The process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides (I) wherein R1 is H or C1-5 alkyl, and R2 is C1-5 alkyl, starts from the corresponding 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-7,7-dioxides, and comprises protecting the alkylamine group, introducing a sulfonamide group and eliminating protecting group. Some compounds of formula (I) are inhibitors of the carbonic anhydrase and can be used in the treatment of elevated intraocular pressure.