40396-53-0

Basic information

• Product Name: 3'-BROMO-2-PHENYLACETOPHENONE
• Synonyms: 3'-BROMO-2-PHENYLACETOPHENONE;1-(3-broMophenyl)-2-phenyl-ethanone
• CAS NO: 40396-53-0
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.14
• Mol File: 40396-53-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 379.4°C at 760 mmHg
• Flash Point: 81.9°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 5.88E-06mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 3'-BROMO-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-BROMO-2-PHENYLACETOPHENONE(40396-53-0)
• EPA Substance Registry System: 3'-BROMO-2-PHENYLACETOPHENONE(40396-53-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 40396-53-0(Hazardous Substances Data)

Usage

General Description

3'-Bromo-2-phenylacetophenone is a chemical compound with the molecular formula C14H11BrO. It is a derivative of acetophenone and contains a bromine atom and a phenyl group attached to the carbon backbone. 3'-BROMO-2-PHENYLACETOPHENONE is commonly used in the production of pharmaceuticals, agrochemicals, and materials science, where its unique structure and properties make it valuable for a variety of applications. It may also be used as an intermediate in organic synthesis, and its bromine substituent makes it particularly useful for reactions involving nucleophilic substitution or metal-catalyzed cross-coupling. As with any chemical compound, proper handling and storage of 3'-Bromo-2-phenylacetophenone are essential to ensure safety and prevent hazardous conditions.

InChI:InChI=1/C14H11BrO/c15-13-8-4-7-12(10-13)14(16)9-11-5-2-1-3-6-11/h1-8,10H,9H2

Upstream product

• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 100-52-7 benzaldehyde 
• 89598-96-9 (3-bromophenyl)boronic acid 
• 140-29-4 phenylacetonitrile 
• 2039-86-3 3-bromostyrene 
• 100-63-0 phenylhydrazine 
• 103-82-2 phenylacetic acid 
• 585-76-2 m-bromobenzoic acid 
• 6952-59-6 3-cyanobromobenzene 
• 100-44-7 benzyl chloride 

Downstream Products

• 40396-55-2 3-bromo-α,α,α',α'-tetrafluorobibenzyl 
• 40396-56-3 2-<3-(α,α,β,β-Tetrafluorphenethyl)phenyl>propan-2-ol 
• 1283117-62-3 3-(6-(3-ethoxy-4-hydroxy-5-nitrophenyl)-2-oxo-5-phenyl-1,2,3,6-tetrahydropyrimidin-4-yl)benzonitrile 
• 758710-68-8 3-(2-phenylacetyl)benzonitrile 
• 1260215-57-3 (R)-2-benzyl-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-4-amine 
• 1260215-56-2 2-benzyl-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-4-amine 
• 1260214-94-5 2-benzyl-2-(3-bromophenyl)-5-methyl-2H-imidazol-4-amine 
• 1260214-93-4 2-benzyl-2-(3-bromophenyl)-5-(methylthio)-2H-imidazol-4-amine 
• 1260214-92-3 5-amino-2-benzyl-2-(3-bromophenyl)-2H-imidazole-4-thiol 
• 40396-54-1 1-(3-bromophenyl)-2-phenylethane-1,2-dione 

Relevant articles and documents

Regioselection in the synthesis of 4-benzyltetral-1-ones and the new 4-arylbenzosuber-1-ones

The intramolecular Friedel-Crafts acylation of 4,5-diarylpentanoic acids has the possibility to cyclise to either a 6-membered ring to give 4-benzyltetral-1-one or a 7-membered ring to give 4-arylbenzosuber-1-one. Of these, only the former compound class has previously been reported. The impact of the substituents positioning on the outcome of the cyclisation has been investigated. The complete formation of either the tetralone or the benzosuberone regioisomer was possible under the same reaction conditions, dependent upon the ring activation and/or deactivation of the chosen substituents. Selected bromo or methoxy substituents could be used as auxiliaries, included in precursors to afford the desired regioisomer and then subsequently removed.

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

Metal-free synthesis of ketones by visible-light induced aerobic oxidative radical addition of aryl hydrazines to alkenes

A green and cost-effective method has been developed for the conversion of alkenes to ketones under metal-free conditions. The reaction involves the oxidative addition of alkenes with aryl radicals, which are generated by visible-light induced aerobic oxidation of arylhydrazines. The key features of this reaction include broad substrate scope, readily available reagents and amenability to gram-scale synthesis.