40401-41-0

Basic information

• Product Name: 2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: AKOS BBS-00006910;1-(3-CHLOROPHENYL)-3-METHYL-1H-PYRAZOL-5-AMINE;1-(3'-CHLOROPHENYL)-3-METHYL-5-AMINOPYRAZOL;2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE;TIMTEC-BB SBB011183;1-(m-chlorophenyl)-3-methyl-5-aminopyrazole;1-(3-Chlorophenyl)-3-methyl-5-amino-1H-pyrazole;2-(3-Chlorophenyl)-5-methyl-2H-pyrazole-3-amine
• CAS NO: 40401-41-0
• Molecular Formula: C₁₀H₁₀ClN₃
• Molecular Weight: 207.66
• Mol File: 40401-41-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 371.2 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(40401-41-0)
• EPA Substance Registry System: 2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(40401-41-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 40401-41-0(Hazardous Substances Data)

Usage

General Description

2-(3-chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine is a chemical compound with the molecular formula C10H10ClN3. It is a pyrazole derivative with a chlorine-substituted phenyl group and a methyl group attached to the pyrazole ring. 2-(3-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE has potential applications in the pharmaceutical industry, specifically in the development of new drugs targeting specific biological pathways. It may also have uses in the field of organic synthesis and chemical research as a building block for the creation of other compounds with similar structures or properties. Additionally, its unique chemical structure and reactivity make it an interesting subject for further study in the field of organic chemistry and chemical biology.

InChI:InChI=1/C10H10ClN3/c1-7-5-10(12)14(13-7)9-4-2-3-8(11)6-9/h2-6H,12H2,1H3

Upstream product

• 2469-99-0 Cyanoaceton 
• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 91587-54-1 Cyanaceton-(3-chlor-phenylhydrazon) 
• 14763-20-3 3-chlorophenyl hydrazine 
• 1118-61-2 3-Aminocrotononitrile 
• 108-42-9 3-chloro-aniline 
• 1001-56-5 buta-2,3-dienenitrile 

Downstream Products

• 1026793-53-2 2-{[2-(3-chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamino]-methylene}-malonic acid diethyl ester 
• 1026129-19-0 4-chloro-1-(3-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 
• 851521-10-3 4-chloro-1-(3-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 1027931-56-1 4-chloro-1-(3-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 1027307-76-1 4-chloro-1-(3-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 124325-26-4 1-(3-Chlorophenyl)-3-methyl-4-benzamido-5-aminopyrazole 
• 124325-23-1 3-phenyl-5-methyl-7-(3-chlorophenyl)-6,7-dihydropyrazolo<3,4-c><1,2,5>thiadiazine 2,2-dioxide 
• 1260163-43-6 N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide 

Relevant articles and documents

Phenoxydifluoromethyl substituted nitrogen heterocycles. Synthesis and heterocyclization reactions of ethyl 4,4-difluoro-4-phenoxyacetoacetate

Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5-benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b] pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles.

One-pot three-component synthesis of a series of 4-aroyl-1,6-diaryl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in the presence of aluminum oxide as a nanocatalyst

[Figure not available: see fulltext.] One-pot three-component reaction of arylglyoxals, 3-aryl-3-oxopropanenitriles, and 5-amino-1-aryl-3-methylpyrazoles using various solvent systems and different catalysts under reflux conditions afforded the corresponding 4-aroyl-1,6-diaryl-3-methyl-1H-pyrazolo[3,4-b]- pyridine-5-carbonitrile derivatives. The best yields (70–91%) were obtained using Al2O3 as a nanocatalyst in H2O–EtOH, 1:1, under reflux conditions. The simplicity of workup procedure, the novelty of pyrazolopyridines, green solvent system, easy preparation of a nanocatalyst, and good to excellent yields of the products are the advantages of this synthetic strategy. The structures of all products were confirmed by FT-IR, 1H and13C NMR, and mass spectral data.

SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.