40418-44-8

Basic information

• Product Name: POTASSIUM GLUTACONATE
• Synonyms: POTASSIUM GLUTACONATE;potassium (1E,3E)-5-oxopenta-1,3-dien-1-olate
• CAS NO: 40418-44-8
• Molecular Formula: C₅H₅O₂*K
• Molecular Weight: 168.19
• Product Categories: Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Miscellaneous Reagents;Aliphatics
• Mol File: 40418-44-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: POTASSIUM GLUTACONATE(CAS DataBase Reference)
• NIST Chemistry Reference: POTASSIUM GLUTACONATE(40418-44-8)
• EPA Substance Registry System: POTASSIUM GLUTACONATE(40418-44-8)

Safety Data

• Hazardous Substances Data: 40418-44-8(Hazardous Substances Data)

Usage

Description

POTASSIUM GLUTACONATE, with the CAS number 40418-44-8, is a light brown solid compound that is primarily utilized in the field of organic synthesis. It serves as a versatile building block for the creation of various organic compounds and plays a significant role in the synthesis of complex molecules.

Uses

Used in Organic Synthesis:
POTASSIUM GLUTACONATE is used as a synthetic building block for the creation of a wide range of organic compounds. Its unique chemical properties allow it to be a valuable component in the synthesis of complex molecules, contributing to the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
POTASSIUM GLUTACONATE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its role in the development of new drugs is crucial, as it can be used to create molecules with specific therapeutic properties, potentially leading to the discovery of novel treatments for various diseases and conditions.
Used in Chemical Research:
POTASSIUM GLUTACONATE is also employed as a research tool in the field of chemistry. Its unique properties make it an interesting subject for study, allowing scientists to explore new reaction pathways and develop innovative synthetic strategies. This research can lead to a better understanding of chemical processes and the development of new methodologies in organic chemistry.

Upstream product

• 42824-16-8 pyridine-SO₃ complex 
• 4688-60-2 Zincke aldehyde 
• 26412-87-3 sulfur trioxide pyridine complex 

Downstream Products

• 77226-50-7 5-(2,4,6-trimethylbenzoyloxy)-2E,4E-pentadienal 
• 1219005-87-4 (2E,4E)-5-(benzylamino)penta-2,4-dienal 
• 1033950-81-0 (2E,4E)-5-(dibenzylamino)penta-2,4-dienal 
• 660430-03-5 neuroprotectin D1 
• 552830-51-0 Resolvin E₁ 
• 916888-47-6 resolvin D3 
• 1132757-67-5 (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal 
• 71160-24-2 Leukotriene B 
• 83058-42-8 Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate 
• 1312756-65-2 (2R,6E,8E,10S)-12-methoxy-12-oxododeca-6,8-diene-2,10-diyl (2R,2'R)-bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate) 
• 1352708-26-9 C₂₃H₂₄N₂OSe 
• 1338801-66-3 C₃₈H₄₂N₂O₅S₂ 
• 1253523-07-7 (2E,4E)-5-(((S)-1-phenylethyl)amino)penta-2,4-dienal 

Relevant articles and documents

A new bromo trienyne: Synthesis of all-E, conjugated tetra-, penta-, and hexaenes common to oxo polyene macrolide antibiotics

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A pyridinium anionic ring-opening reaction applied to the stereodivergent syntheses of: Piperaceae natural products

A stereodivergent strategy has been devised to access the diene motif found in biologically active compounds from the Piperaceae family. Herein the first total syntheses of 2E,4E configured piperchabamide E (2) and its enantiomer (ent-2), as well as 2E,4Z configured scutifoliamide B (3), are narrated. The mainstay in the adopted approach is the gram-scale conversion of quaternized pyridine in a practical three-step sequence to access isomerically pure conjugated bromodiene esters 2E,4E8 and 2E,4Z9 by differential crystallization. Even though the developed oxidation protocol forms the basis of the entailed divergent strategy, the geometrical integrity of the involved bromodiene motive can be controlled by the choice of solvent. Thus, while oxidation of pure bromodienal 2E,4Z7 in methanol yields equal amounts of bromodiene esters 2E,4E8 and 2E,4Z9, only bromodiene ester 2E,4Z10 is formed in isopropanol. Subseqently, capitalizing on a stereoretentive Suzuki cross-coupling and direct amidation of the corresponding esters, the featured natural products can be accessed in five and six steps, respectively. The somewhat surprising (R)-configured amine portion, which has been assigned to piperchabamide E (2), is facilitated by a Curtius rearrangement. Following this, the actual amine portion is shown to be (S)-configured. This journal is

Stereoselective synthesis of protectin D1: A potent anti-inflammatory and proresolving lipid mediator

A convergent stereoselective synthesis of the potent anti-inflammatory, proresolving and neuroprotective lipid mediator protectin D1 (2) has been achieved in 15% yield over eight steps. The key features were a stereocontrolled Evans-aldol reaction with Nagao's chiral auxiliary and a highly selective Lindlar reduction of internal alkyne 23, allowing the sensitive conjugated E,E,Z-triene to be introduced late in the preparation of 2. The UV and LC/MS-MS data of synthetic protectin D1 (2) matched those obtained from endogenously produced material.