404345-06-8

Basic information

• Product Name: 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 404345-06-8
• Molecular Formula: C14H19NO2S
• Molecular Weight: 265.376
• Mol File: 404345-06-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]-(404345-06-8)
• EPA Substance Registry System: 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]-(404345-06-8)

Safety Data

• Hazardous Substances Data: 404345-06-8(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 15 carbon (C), 23 hydrogen (H), 1 nitrogen (N), 2 oxygen (O), and 1 sulfur (S) atoms.

Explanation

Azaspiroalkane sulfonamides are a group of organic compounds that contain a sulfonyl-methylene moiety linked to an azaspiro[2.5]octane moiety. This class of compounds has potential applications in medicinal chemistry and drug discovery.

Explanation

The sulfonyl-methylene moiety is a functional group that consists of a sulfur atom double-bonded to an oxygen atom and single-bonded to a methylene group (-CH2-). In this compound, the sulfonyl-methylene moiety is connected to a 4-methylphenyl group.

Explanation

Due to its unique structure and properties, 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]may have potential applications in the field of medicinal chemistry and drug discovery. It could potentially be used to develop new drugs or therapies by targeting specific enzymes or receptors.

Explanation

The compound may possess biological activities such as enzyme inhibition or receptor modulation, which are important for its potential use in drug discovery. Enzyme inhibition involves blocking the activity of an enzyme, while receptor modulation involves altering the way a receptor interacts with its target molecule.

Explanation

Although 1-Azaspiro[2.5]octane, 1-[(4-methylphenyl)sulfonyl]has potential applications in medicinal chemistry and drug discovery, more research is needed to fully understand its potential uses and effects on biological systems. This may involve studying its interactions with various enzymes, receptors, and other cellular targets.

Class

Azaspiroalkane sulfonamides

Structure

Spiro ring system with a nitrogen atom

Sulfonyl-methylene moiety

(4-methylphenyl)sulfonyl

Potential Applications

Medicinal chemistry and drug discovery

Biological Activities

Enzyme inhibition or receptor modulation

Further Research

Required to understand potential uses and effects

Upstream product

• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 1192-37-6 methylenecyclohexane 
• 1058-14-6 N-p-tolylsulfonylphosphine imide 
• 127-65-1 chloroamine-T 
• 41085-71-6 bromamine T 

Downstream Products

• 1207755-59-6 C₅₂H₇₅NO₇S 
• 905982-94-7 1-(toluene-4-sulfonyl)-1-aza-spiro[5.5]undec-2-ene 
• 404345-07-9 1-(4-toluenesulfonyl)amido-1-bromomethylcyclohexane 

Relevant articles and documents

A versatile tripodal Cu(I) reagent for C-N bond construction via nitrene-transfer chemistry: Catalytic perspectives and mechanistic insights on C-H aminations/amidinations and olefin aziridinations

A CuI catalyst (1), supported by a framework of strongly basic guanidinato moieties, mediates nitrene-transfer from PhI=NR sources to a wide variety of aliphatic hydrocarbons (C-H amination or amidination in the presence of nitriles) and olefins (aziridination). Product profiles are consistent with a stepwise rather than concerted C-N bond formation. Mechanistic investigations with the aid of Hammett plots, kinetic isotope effects, labeled stereochemical probes, and radical traps and clocks allow us to conclude that carboradical intermediates play a major role and are generated by hydrogen-atom abstraction from substrate C-H bonds or initial nitrene-addition to one of the olefinic carbons. Subsequent processes include solvent-caged radical recombination to afford the major amination and aziridination products but also one-electron oxidation of diffusively free carboradicals to generate amidination products due to carbocation participation. Analyses of metal- and ligand-centered events by variable temperature electrospray mass spectrometry, cyclic voltammetry, and electron paramagnetic resonance spectroscopy, coupled with computational studies, indicate that an active, but still elusive, copper-nitrene (S = 1) intermediate initially abstracts a hydrogen atom from, or adds nitrene to, C-H and C=C bonds, respectively, followed by a spin flip and radical rebound to afford intra- and intermolecular C-N containing products.

ANTIFUNGAL AGENTS

Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs,,as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

Cobalt-catalyzed efficient aziridination of alkenes

(Chemical Equation Presented) Cobalt porphyrins are capable of catalyzing the aziridination of alkenes with bromamine-T as the nitrene source. Among cobalt complexes of different porphyrins, Co(TDCIPP) is an effective catalyst that can aziridinate a wide