40453-77-8

Basic information

• Product Name: 2,3-dimethoxypropan-1-ol
• Synonyms: 1-propanol, 2,3-dimethoxy-; 2,3-Dimethoxypropan-1-ol
• CAS NO: 40453-77-8
• Molecular Formula: C₅H₁₂O₃
• Molecular Weight: 120.147
• Mol File: 40453-77-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 179.999°C at 760 mmHg
• Flash Point: 62.802°C
• Density: 0.987g/cm³
• Vapor Pressure: 0.271mmHg at 25°C
• Refractive Index: 1.411
• PKA: 14.20±0.10(Predicted)
• CAS DataBase Reference: 2,3-dimethoxypropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethoxypropan-1-ol(40453-77-8)
• EPA Substance Registry System: 2,3-dimethoxypropan-1-ol(40453-77-8)

Safety Data

• Hazardous Substances Data: 40453-77-8(Hazardous Substances Data)

Usage

General Description

2,3-dimethoxypropan-1-ol is a chemical compound with the molecular formula C5H12O3. It is a colorless liquid with a mildly sweet odor, and it is used as a solvent and intermediate in the production of pharmaceuticals, fragrances, and other organic compounds. This chemical is also known by its synonyms such as "β-Methyltetrahydroxyisopropyl ether" and "3-(2-Methoxyethoxy)-1-propanol." It is commonly used in the manufacturing of cosmetics, paints, and coatings, as well as in the production of pesticides and herbicides. Additionally, 2,3-dimethoxypropan-1-ol is often utilized as a propellant in aerosol sprays. However, it is important to handle this chemical with care as it can be hazardous if not used properly and is harmful if swallowed or inhaled, causing irritation to the eyes, skin, and respiratory system.

Upstream product

• 96-13-9 2,3-Dibromopropan-1-ol 
• 124-41-4 sodium methylate 
• 34680-56-3 1-Chlor-2,3-dimethoxy-propane 
• 56-81-5 glycerol 
• 77-78-1 dimethyl sulfate 
• 105444-34-6 2,3-di-O-methyl-DL-glyceraldehyde 
• 1972-28-7 diethylazodicarboxylate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 28959-03-7 1-benzyloxy-2,3-dimethoxypropane 
• 1872-45-3 3-Methoxyoxetan 

Downstream Products

• 78-98-8 2-oxopropanal 

Relevant articles and documents

Cyclopentadienyl and pentamethylcyclopentadienyl ruthenium complexes as catalysts for the total deoxygenation of 1,2-hexanediol and glycerol

The ruthenium aqua complexes [cp*Ru(OH2)(N-N)](OTf) (cp* = η5-pentamethylcyclopentadienyl, N-N = 2,2′-bipyridine, phen = 1,10-phenanthroline, OTf- = trifluoromethanesulfonate) and the acetonitrile complex [cpRu(CH 3CN)(bipy)](OTf) (cp = η5-cyclopentadienyl) are water-, acid-, and thermally stable (>200°C) catalysts for the hydrogenation of aldehydes and ketones in sulfolane solution. In the presence of HOTf as a co-catalyst, they effect the deoxygenation of 1,2-hexanediol to 1-hexanol and hexane. Glycerol is deoxygenated to 1-propanol in up to 18% yield and under more forcing conditions completely deoxygenated to propene. The structure of the acetonitrile pro-catalyst [cpRu(CH3CN)(bipy)](OTf) has been determined by X-ray crystallography (space group P1 (a = 9.3778(10) A; b = 10.7852(10) A; c = 11.1818(13) A; α = 101.718(5)°; β = 114.717(4)°; γ = 102.712(5)°; R = 3.95%).

2-PHENYL-6-AMINOCARBONYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS

The invention relates to 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. Formula (I).