404584-29-8

Basic information

• Product Name: 2-cyclohexyl-5-methyl-1,3-benzoxazole
• Synonyms: 2-cyclohexyl-5-methyl-1,3-benzoxazole
• CAS NO: 404584-29-8
• Molecular Weight: 215.295
• Mol File: 404584-29-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-cyclohexyl-5-methyl-1,3-benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexyl-5-methyl-1,3-benzoxazole(404584-29-8)
• EPA Substance Registry System: 2-cyclohexyl-5-methyl-1,3-benzoxazole(404584-29-8)

Safety Data

• Hazardous Substances Data: 404584-29-8(Hazardous Substances Data)

Upstream product

• 110-82-7 cyclohexane 
• 621-29-4 3-tolyl isocyanate 
• 83354-06-7 3-cyclohexyl-1-phenyl-2-propyn-1-one 
• 95-84-1 3-amino-4-hydroxytoluene 
• 10531-78-9 5-methyl-1,3-benzoxazole 
• 626-62-0 Cyclohexyl iodide 
• 4545-18-0 N'-cyclohexylidene-4-methylbenzene-1-sulfonohydrazide 

Relevant articles and documents

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of β-iminoketones/elimination of acetophenone promoted by the copper catalyst.

A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.