404586-95-4

Basic information

• Product Name: Carbonic acid, 1,1-dimethylethyl 4-methoxyphenyl ester
• CAS NO: 404586-95-4
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol File: 404586-95-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Carbonic acid, 1,1-dimethylethyl 4-methoxyphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid, 1,1-dimethylethyl 4-methoxyphenyl ester(404586-95-4)
• EPA Substance Registry System: Carbonic acid, 1,1-dimethylethyl 4-methoxyphenyl ester(404586-95-4)

Safety Data

• Hazardous Substances Data: 404586-95-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 150-76-5 4-methoxy-phenol 
• 404586-94-3 1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline 

Downstream Products

• 15360-00-6 p-tert-butoxyanisole 
• 150-76-5 4-methoxy-phenol 

Relevant articles and documents

Anionic Fries rearrangement of aryl carbonates. A facile route to ortho-hydroxy esters

Aryl carbonates react with LDA or LiTMP to produce ortho-hydroxy esters.

A new, efficient, and catalyst-free microwave-assisted approach for formation of O-tert-butoxy carbonates

A new simple, efficient, greener, and catalyst-free chemoselective protocol for the O-tert-butoxycarbonylation of various structurally diverse hydroxy compounds was carried out with (Boc)2O under microwave radiation. The corresponding O-tertbutoxy carbonates were obtained in good to excellent yields in a short reaction time without any side reactions.

Nickel catalyzed cross-coupling of aryl C-O based electrophiles with aryl neopentylglycolboronates

The efficiency of mesylates, sulfamates, esters, carbonates, carbamates, and methyl ethers as C-O-based electrophiles attached to the 1- or 2-position of naphthalene and to activated and nonactivated phenyl substrates was compared for the first time in Ni-catalyzed cross-coupling with phenyl neopentylglycolboronates containing electron-rich and electron-deficient substituents in their para-position. These experiments were performed in the presence of four different Ni(II)- and Ni(0)-based catalysts. Ni(II)-based catalysts mediate the cross-coupling of most 2-naphthyl C-O electrophiles with both arylboronic acids and with neopentylglycolboronates when K 3PO4 is used as base. The same catalysts are not efficient when CsF is used as base. However, Ni(0)-based catalysts exhibit selective efficiency, and when reactive, their efficiency is higher than that of Ni(II)-based catalysts in the presence of both K3PO4 and CsF. These results provide both reaction conditions for the cross-coupling, and for the elaboration of orthogonal cross-coupling methodologies of various C-O based electrophiles with aryl neopentylglycolboronates. With the exception of mesylates and sulfamates the efficiency of all other 2-naphthyl C-O electrophiles was lower in cross-coupling with aryl neopentylglycolboronates than with arylboronic acids