40525-78-8

Basic information

• Product Name: 4α-Aminocyclohexan-1α-ol
• Synonyms: cis-4-Aminocyclohexanol;Cis-aminohexanol;Ambroxol Impurity 6
• CAS NO: 40525-78-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• EINECS: 1308068-626-2
• Mol File: 40525-78-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 75.4 °C
• Appearance: /
• Density: 1.037
• PKA: 15.12±0.40(Predicted)
• CAS DataBase Reference: 4α-Aminocyclohexan-1α-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4α-Aminocyclohexan-1α-ol(40525-78-8)
• EPA Substance Registry System: 4α-Aminocyclohexan-1α-ol(40525-78-8)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 40525-78-8(Hazardous Substances Data)

Usage

General Description

4α-Aminocyclohexan-1α-ol is a chemical compound with a cyclohexane ring and an amino group. It is primarily used in research and development, particularly in the field of organic synthesis and medicinal chemistry. 4α-Aminocyclohexan-1α-ol has potential applications in the pharmaceutical industry, particularly in the development of new drugs and medications. It is known for its ability to interact with biological systems, and its structure makes it a valuable building block for the synthesis of various complex molecules. Additionally, it has potential uses in the development of new materials and technologies due to its unique chemical properties and reactivity. Overall, 4α-Aminocyclohexan-1α-ol is a versatile compound with promising potential for various applications in science and industry.

InChI:InChI=1S/C6H13NO/c7-5-1-3-6(8)4-2-5/h5-6,8H,1-4,7H2

Upstream product

• 100-02-7 4-nitro-phenol 
• 27489-61-8 cis-(N-4-hydroxycyclohexyl)acetamide 
• 123-30-8 4-amino-phenol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 123-31-9 hydroquinone 
• 103-90-2 4-acetaminophenol 

Downstream Products

• 27489-61-8 cis-(N-4-hydroxycyclohexyl)acetamide 
• 64979-91-5 cis-(4-hydroxycyclohexyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione 
• 1013099-80-3 cis-4-{[5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidin-4-yl]amino}cyclohexanol 
• 1431626-38-8 methyl [(cis-4-{[5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidin-4-yl]amino}cyclohexyl)oxy]acetate 
• 1431626-39-9 2-[(cis-4-{[5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidin-4-yl]amino}cyclohexyl)oxy]acetamide 
• 1431626-40-2 2-({cis-4-[(2-amino-5-bromo-6-methylpyrimidin-4-yl)amino]cyclohexyl}oxy)acetamide 
• 1431626-41-3 ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate 
• 1431626-42-4 2-{[cis-4-(2-amino-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)cyclohexyl]oxy}acetamide 
• 1431626-43-5 2-{[cis-4-(2-amino-6-bromo-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)cyclohexyl]oxy}acetamide 
• 1013101-53-5 2-({cis-4-[2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]cyclohexyl}oxy)acetamide 
• 1013101-54-6 C₂₂H₂₅FN₆O₄ 
• 1013101-57-9 C₂₁H₂₅N₇O₄ 
• 1013101-58-0 C₂₅H₂₆N₆O₃ 
• 167081-25-6 cis-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester 

Relevant articles and documents

The Rhodium Catalysed Direct Conversion of Phenols to Primary Cyclohexylamines

Cyclohexylamines are important intermediates in chemical industry, which are currently produced from petrochemical sources. Phenols, however, are an attractive sustainable feedstock. We here demonstrate the transformation of phenols with ammonia to primary cyclohexylamines. In contrast to previously reported chemistry which used palladium catalysts, we here show that rhodium is an excellent catalyst for the formation of primary cyclohexylamines. Different parameters were studied and it was shown that the reaction is applicable to a scope of phenolic compounds providing high selectivity.