405261-70-3

Basic information

• Product Name: (1S,4R,5R,8R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.^4,130^8,13]hexadec-2-ene
• Synonyms: (1S,4R,5R,8R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.^4,130^8,13]hexadec-2-ene
• CAS NO: 405261-70-3
• Molecular Weight: 334.336
• Mol File: 405261-70-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,4R,5R,8R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.^4,130^8,13]hexadec-2-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4R,5R,8R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.^4,130^8,13]hexadec-2-ene(405261-70-3)
• EPA Substance Registry System: (1S,4R,5R,8R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.^4,130^8,13]hexadec-2-ene(405261-70-3)

Safety Data

• Hazardous Substances Data: 405261-70-3(Hazardous Substances Data)

Upstream product

• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 408347-42-2 10-bromo-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0^4,13.0^8,13]hexadecane 
• 104-94-9 4-methoxy-aniline 

Relevant articles and documents

Preparation of 10-Trifluoromethyl Artemether and Artesunate. Influence of Hexafluoropropan-2-ol on Substitution Reaction

To prepare 10-trifluoromethyl analogues of important antimalarials such as artemether and artesunate, the substitution reaction of the 10-trifluoromethyl hemiketal 6 and bromide 4 derived from artemisinin was investigated. While 6 appeared to be unreactiv