4053-36-5

Basic information

• Product Name: 2-Hydroxy-8-methylquinoline
• Synonyms: 2-Hydroxy-8-methylquinoline;8-Methylquinolin-2(1H)-one;8-Methyl-2(1H)-quinolinone
• CAS NO: 4053-36-5
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• Mol File: 4053-36-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 219-220 °C
• Boiling Point: 339.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.81±0.70(Predicted)
• CAS DataBase Reference: 2-Hydroxy-8-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-8-methylquinoline(4053-36-5)
• EPA Substance Registry System: 2-Hydroxy-8-methylquinoline(4053-36-5)

Safety Data

• Hazardous Substances Data: 4053-36-5(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-8-methylquinoline, also known as 8-Methyl-2-quinolone or 8-Methylquinolin-2(1H)-one, is an organic compound with the molecular formula C10H9NO. It is a quinoline derivative with a hydroxy group attached to the 2-position and a methyl group at the 8-position. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It exhibits a variety of biological activities, including antimicrobial, antiviral, and antitumor properties, making it a valuable component in the development of new drugs. Additionally, 2-Hydroxy-8-methylquinoline has been studied for its potential as a corrosion inhibitor and as a fluorescent probe for metal ions in analytical chemistry.

Upstream product

• 20151-45-5 2-Amino-8-methyl-chinolin 
• 4225-85-8 2-chloro-8-methylquinoline 
• 124-41-4 sodium methylate 
• 611-32-5 8-methylquinoline 
• 95-53-4 o-toluidine 
• 78987-21-0 (E)-N-(2-methylphenyl)-3-phenylacrylamide 
• 4053-38-7 8-methylquinoline 1-oxide 
• 140-88-5 ethyl acrylate 
• 78987-21-0 N-(2-methylphenyl)-3-phenylacrylamide 
• 1035669-80-7 C₁₂H₁₃NO 
• 885687-65-0 2-methoxy-8-methyl-quinoline 

Downstream Products

• 99073-81-1 2-bromo-8-methylquinoline 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 4225-85-8 2-chloro-8-methylquinoline 

Relevant articles and documents

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C-Bridged Bispyrrolidines and Bispiperidines as New Ligands

The preparation of methylene-bridged C2-symmetric nitrogen-heterocycles as a new class of ligands is described, including methylene-bridged pyridines, quinolones, piperidines and pyrrolidines. These methylene-bridged aromatic systems are obtained via a microwave assisted Ziegler-type reaction. The separation of diastereomers and the application of the copper complexes of these ligands for cyclopropanation reactions proves the applicability of these new types of ligands.

A nitrogen oxide C2 - bit hydroxylated method (by machine translation)

The present invention relates to nitrogen oxide C2 - bit hydroxylated method, in particular under reflux conditions in dichloroethane, three pyrrole alkyl bromide (PyBrop) [...] phosphate, sodium acetate, water and nitrogen oxides produced by the reaction of hydroxyl-substituted product. The process has simple operation, mild condition, high reaction selectivity, substrate wide applicability, high yield and the like. The application for the first time using this method to synthesize a series of 2 - hydroxyquinoline, 2 - hydroxy pyridine and 1 - hydroxy isoquinoline compound, in the establishment of the compounds of the library synthesis application have broad prospects. (by machine translation)