40533-25-3 Usage
Uses
Cyclapolin 9 is a selective and ATP-competitive Plk inhibitor.
Biological Activity
Selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC 50 = 500 nM).
Check Digit Verification of cas no
The CAS Registry Mumber 40533-25-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,5,3 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 40533-25:
(7*4)+(6*0)+(5*5)+(4*3)+(3*3)+(2*2)+(1*5)=83
83 % 10 = 3
So 40533-25-3 is a valid CAS Registry Number.
40533-25-3Relevant articles and documents
The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1
Pearson, Russell J.,Blake, David G.,Mezna, Mokdad,Fischer, Peter M.,Westwood, Nicholas J.,McInnes, Campbell
, p. 1107 - 4,1116 (2018)
The polo kinase family are important oncology targets that act in regulating entry into and progression through mitosis. Structure-guided discovery of a new class of inhibitors of Polo-like kinase 1 (PLK1) catalytic activity that interact with Cys67 of th
