40534-33-6

Basic information

• Product Name: 1-(1-Methyl-1H-pyrazol-4-yl)ethanol
• Synonyms: 1-(1-Methyl-1H-pyrazol-4-yl)ethanol;1-(1-Methylpyrazol-4-yl)ethanol;1H-Pyrazole-4-Methanol, a,1-diMethyl-
• CAS NO: 40534-33-6
• Molecular Formula: C6H10N2O
• Molecular Weight: 126.158
• Mol File: 40534-33-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.507 °C at 760 mmHg
• Flash Point: 96.836 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 0.026mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 1-(1-Methyl-1H-pyrazol-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Methyl-1H-pyrazol-4-yl)ethanol(40534-33-6)
• EPA Substance Registry System: 1-(1-Methyl-1H-pyrazol-4-yl)ethanol(40534-33-6)

Safety Data

• Hazardous Substances Data: 40534-33-6(Hazardous Substances Data)

Usage

General Description

1-(1-Methyl-1H-pyrazol-4-yl)ethanol, also known as ethanolamine, is a chemical compound with a molecular formula C6H10N2O. It is a colorless liquid that is commonly used as a solvent and intermediate in the production of various products such as pharmaceuticals, herbicides, and corrosion inhibitors. Ethanolamine is also used in the synthesis of surfactants and as a precursor for the production of ethyleneamines, which are used in a variety of applications including detergents, textile additives, and fuel additives. Additionally, it is used in the manufacturing of personal care products such as shampoos, hair conditioners, and soaps. Due to its versatile applications, ethanolamine is widely used in various industries and is an important component in the production of numerous consumer and industrial products.

InChI:InChI=1/C6H10N2O/c1-5(9)6-3-7-8(2)4-6/h3-5,9H,1-2H3

Upstream product

• 37687-18-6 1-(1-methyl-1H-pyrazol-4-yl)-1-ethanone 
• 25016-11-9 1-methylpyrazole-4-carbaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 37687-18-6 1-(1-methyl-1H-pyrazol-4-yl)-1-ethanone 

Relevant articles and documents

Discovery, design, and synthesis of indole-based EZH2 inhibitors

The discovery and optimization of a series of small molecule EZH2 inhibitors is described. Starting from dimethylpyridone HTS hit (2), a series of indole-based EZH2 inhibitors were identified. Biochemical potency and microsomal stability were optimized during these studies and afforded compound 22. This compound demonstrates nanomolar levels of biochemical potency (IC50 = 0.002 μM), cellular potency (EC50 = 0.080 μM), and afforded tumor regression when dosed (200 mpk SC BID) in an EZH2 dependent tumor xenograft model.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.