40546-41-6

Basic information

• Product Name: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER
• Synonyms: ETHYL 4-CHLOROBENZIMIDATE HYDROCHLORIDE;4-Chloro-benzenecarboxiMidic Acid Ethyl Ether Hydrochloride;4-ChlorobenziMidoyl Ethyl Ether Hydrochloride;Ethyl p-ChlorobenziMidate Hydrochloride;4-Chlorobenzimidic acid ethyl ester hydrochloride;4-Chlorobenzimidic acid methyl ester hydrochloride;Methyl 4-chlorobenzimidate hydrochloride;Ethyl 4-chlorobenzenecarboximidate hydrochloride
• CAS NO: 40546-41-6
• Molecular Formula: C₉H₁₀ClNO*ClH
• Molecular Weight: 220.1
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 40546-41-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform
• CAS DataBase Reference: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(40546-41-6)
• EPA Substance Registry System: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(40546-41-6)

Safety Data

• Hazardous Substances Data: 40546-41-6(Hazardous Substances Data)

Usage

Description

4-Chloro-benzimidoyl Ethyl Ether, also known as 4-Chloro-benzimidoyl Ethyl Ether Hydrochloride, is a white solid chemical compound. It is a useful reagent in the synthesis of novel 3,5-disubstituted-1,2,4-triazoles and is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4-Chloro-benzimidoyl Ethyl Ether is used as a reagent for the synthesis of 3,5-disubstituted-1,2,4-triazoles, which are important compounds in the development of new pharmaceuticals. These triazoles have shown potential in various therapeutic applications, making this compound a valuable asset in drug discovery and development.
Used in Chemical Research:
As a reagent, 4-Chloro-benzimidoyl Ethyl Ether is used in chemical research for evaluating the antibacterial, antiurease, and antioxidant activities of synthesized compounds. Its role in these evaluations helps researchers understand the potential applications and effectiveness of newly developed substances.
Used in Material Science:
The unique chemical properties of 4-Chloro-benzimidoyl Ethyl Ether make it a candidate for use in material science, where it can be employed in the development of new materials with specific properties, such as improved antibacterial or antioxidant characteristics.

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 75-36-5 acetyl chloride 
• 3848-36-0 4-chlorobenzaldoxime 
• 104-88-1 4-chlorobenzaldehyde 
• 64-17-5 ethanol 

Downstream Products

• 14401-51-5 4-chlorobenzamidine hydrochloride 
• 1333221-42-3 methyl 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate 
• 300800-07-1 methyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate 
• 1370731-53-5 methyl 2-(p-chlorophenyl)-5-phenyloxazole-4-carboxylate 
• 1370731-54-6 C₂₂H₁₄Cl₂N₂O₆ 
• 1617508-83-4 2,4-dichloro-5-[5-(4-chlorophenyl)-1,2,4-triazol-3-yl]benzenesulfonamide 
• 19563-04-3 p-chlorobenzamidine 
• 827-72-5 4-chlorobenzimidic acid ethyl ester 
• 56107-76-7 3-(4-chlorophenyl)-6-methyl-1,2,4,5-tetrazine 
• 143703-90-6 ethyl p-chlorobenzoate 4-pyridinoylhydrazone 

Relevant articles and documents

Microwave-assisted synthesis of new 2-aryl and 2-alkylimidazolones and evaluation of their in vitro anticancer activity and their in vivo toxicity on zebrafish embryos

Herein we describe the synthesis of five new 2-aryl and 2-alkylimidazolone derivatives via an effective one-pot synthetic strategy assisted by microwave irradiations which allowed us to access the desired product in a reduced time reaction compared to the

Colchicine derivatives, and preparation method and medical application thereof

The invention specifically relates to colchicine derivatives (I) as described in the specification and a preparation method thereof, and pharmaceutical compositions containing the colchicine derivatives, belonging to the field of medicinal chemistry. The results of pharmacodynamic experiments prove that the colchicine derivatives of the invention have treatment effect on lumbar disc herniation andliver fibrosis.

Synthesis and structure of aroylamidines and N-arylbenzamidines hydrochlorides

Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl3. The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation. Pleiades Publishing, Ltd., 2012.