40567-33-7

Basic information

• Product Name: Benzoic acid, 4-methoxy-2-sulfo-
• CAS NO: 40567-33-7
• Molecular Formula: C8H8O6S
• Molecular Weight: 232.214
• Mol File: 40567-33-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-2-sulfo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-2-sulfo-(40567-33-7)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-2-sulfo-(40567-33-7)

Safety Data

• Hazardous Substances Data: 40567-33-7(Hazardous Substances Data)

Upstream product

• 62473-95-4 6-methoxybenzo[d]isothiazol-3(2H)-one 1,1-dioxide 
• 201230-82-2 carbon monoxide 
• 5329-14-6 aminosulfonic acid 
• 13244-33-2 2-amino-5-methoxybenzenesulfonic acid 

Relevant articles and documents

Process development for a herbicide intermediate via catalytic carboxylation of an aromatic diazonium compound

A laboratory process is described for the preparation of 2-sulfo-4-methoxybenzoic acid (SMBA) via diazotization of 2-amino-4-methoxy-sulfonic acid followed by Pd-catalyzed carbonylation in the presence of water. The most important process parameters were the catalyst precursor and water content. Both a two-step procedure using isolated diazonium compound as well as a one-pot reaction proved to be feasible. A yield of > 95% SMBA was obtained after 3-4 h, using 1 mol % PdCl2 at 8 bar and 60°C. This is the first technically feasible catalytic carbonylation of an arene diazonium compound.