405934-28-3

Basic information

• Product Name: 1-[2-(hydroxymethyl)phenyl]-3-phenylthiourea
• Synonyms: 1-[2-(hydroxymethyl)phenyl]-3-phenylthiourea
• CAS NO: 405934-28-3
• Molecular Weight: 258.344
• Mol File: 405934-28-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-[2-(hydroxymethyl)phenyl]-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(hydroxymethyl)phenyl]-3-phenylthiourea(405934-28-3)
• EPA Substance Registry System: 1-[2-(hydroxymethyl)phenyl]-3-phenylthiourea(405934-28-3)

Safety Data

• Hazardous Substances Data: 405934-28-3(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 109768-66-3 N-phenyl-4H-benzo[d][1,3]thiazin-2-amine 
• 128814-70-0 N-phenyl-4H-benzo[d][1,3]oxazin-2-amine 

Relevant articles and documents

A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines

A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.

P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol towards the Synthesis of N,S-Heterocycles and Spiro Compounds

A P(III)-mediated entry towards construction of C?N/C?S bond has been devised. The developed heterocyclization method was exercised for the synthesis of a diverse range of N,S-heterocycles and related spiro molecules. P(NMe2)3 revealed the maximum efficacies under the aerobic reaction conditions and a spectrum of bis-nucleophiles, and isothiocyanates were tolerated well to serve the access of manifold immense molecules. (Figure presented.).

One-pot reaction for the synthesis of N-substituted 2-aminobenzoxazoles using triphenylbismuth dichloride as cyclodesulfurization reagent

The treatment of various 2-aminophenols with isothiocyanates afforded thioureas, which were reacted in situ with triphenylbismuth dichloride in the presence of triethylamine to give the expected N-substituted benzoxazol-2-amines in good to excellent yields. Triphenylbismuth dichloride promoted the successful cyclodesulfurization of thioureas with short reaction times under mild reaction conditions. This reaction is the first example of the synthesis of heterocyclic rings using a pentavalent organobismuth reagent.