405939-48-2 Usage
Description
BENZYL (6-AMINO-5-BROMOPYRIDIN-3-YL)CARBAMATE is a chemical compound characterized by the molecular formula C13H12BrN3O2. It belongs to the carbamate class of organic compounds, which are defined by the functional group C(O)(O)NR2. BENZYL (6-AMINO-5-BROMOPYRIDIN-3-YL)CARBAMATE is primarily recognized for its role as an intermediate in the pharmaceutical industry, facilitating the synthesis of a range of drugs and pharmaceutical compounds. Its potential extends to the treatment of various diseases and medical conditions, and it may also contribute to the field of organic chemistry through the synthesis of other organic compounds. Due to its potential hazards, it is crucial to handle and utilize this chemical with appropriate safety measures.
Uses
Used in Pharmaceutical Industry:
BENZYL (6-AMINO-5-BROMOPYRIDIN-3-YL)CARBAMATE is used as a chemical intermediate for the synthesis of various drugs and pharmaceutical compounds. It plays a crucial role in the development of new medications, contributing to the advancement of healthcare and the treatment of a wide array of diseases and medical conditions.
Used in Organic Chemistry:
In the realm of organic chemistry, BENZYL (6-AMINO-5-BROMOPYRIDIN-3-YL)CARBAMATE is utilized for the synthesis of other organic compounds. Its unique structure and properties make it a valuable component in the creation of new chemical entities, potentially leading to innovative applications and discoveries in the field.
Check Digit Verification of cas no
The CAS Registry Mumber 405939-48-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,9,3 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 405939-48:
(8*4)+(7*0)+(6*5)+(5*9)+(4*3)+(3*9)+(2*4)+(1*8)=162
162 % 10 = 2
So 405939-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H12BrN3O2/c14-11-6-10(7-16-12(11)15)17-13(18)19-8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,15,16)(H,17,18)
405939-48-2Relevant articles and documents
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors
Kuo, Gee-Hong,Prouty, Catherine,Wang, Aihua,Emanuel, Stuart,DeAngelis, Alan,Zhang, Yan,Song, Fengbin,Beall, Lawrence,Connolly, Peter J.,Karnachi, Prahba,Chen, Xin,Gruninger, Robert H.,Sechler, Jan,Fuentes-Pesquera, Angel,Middleton, Steven A.,Jolliffe, Linda,Murray, William V.
, p. 4892 - 4909 (2007/10/03)
There is much evidence that direct inhibition of the kinase activity of vascular endothelial growth factor receptor-2 (VEGFR-2) will result in the reduction of angiogenesis and the suppression of tumor growth. Palladium-catalyzed C-C bond, C-N bond formation reactions were used to assemble various pyrazine-pyridine biheteroaryls as potent VEGFR-2 inhibitors. Among them, 4-{5-[6-(3-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-butan-1-ol (39) and N-{5-[6-(3-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-N′, N′-dimethyl-ethane-1,2-diamine (41) exhibited the highest kinase selectivity against fibroblast growth factor receptor kinase, platelet-derived growth factor receptor kinase, and glycogen synthase kinase-3. All of these compounds showed good cellular potency to inhibit VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) but with modest effects on the unstimulated growth of HUVEC. The low inhibition of these compounds to the growth of tumor cell lines, such as HeLa, HCT-116, and A375 further confirms that these VEGFR-2 inhibitors are not cytotoxic agents. The in vivo antitumor activity of 39 and 41 were demonstrated in the A375 human melanoma xenograft nude mice model. Molecular modeling (QSAR analysis) was conducted in an attempt to rationalize the observed structure-activity relationship.
