406204-74-8

Basic information

• Product Name: 2,4-Dichloro-6-fluoroquinoline
• Synonyms: 2,4-DICHLORO-6-FLUORO-QUINOLINE
• CAS NO: 406204-74-8
• Molecular Formula: C₉H₄Cl₂FN
• Molecular Weight: 216.04
• Mol File: 406204-74-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 290.139 °C at 760 mmHg
• Flash Point: 129.272 °C
• Appearance: /
• Density: 1.491 g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.636
• PKA: -1.80±0.50(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-6-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-6-fluoroquinoline(406204-74-8)
• EPA Substance Registry System: 2,4-Dichloro-6-fluoroquinoline(406204-74-8)

Safety Data

• Hazardous Substances Data: 406204-74-8(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-6-fluoroquinoline is a chemical compound belonging to the quinoline family, which consists of a six-membered aromatic ring fused to a pyridine ring. It is a synthetic compound with the molecular formula C9H5Cl2FN, containing two chlorine atoms and one fluorine atom. 2,4-Dichloro-6-fluoroquinoline is used in the synthesis of pharmaceuticals and agrochemicals. It is also a potential precursor in the production of other organic compounds. 2,4-Dichloro-6-fluoroquinoline possesses certain biological activities and has been studied for its potential pharmacological applications. However, it is important to handle this compound with care, as it may pose health and environmental hazards due to its toxic and reactive nature.

InChI:InChI=1/C9H4Cl2FN/c10-7-4-9(11)13-8-2-1-5(12)3-6(7)8/h1-4H

Upstream product

• 141-82-2 malonic acid 
• 371-40-4 4-fluoroaniline 
• 1663-67-8 malonoyl dichloride 
• 1677-37-8 6-fluoro-4-hydroxy-1H-quinolin-2-one 

Downstream Products

• 1613289-08-9 4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one 
• 1424371-10-7 C₂₈H₂₆ClFN₂O₅ 
• 1424371-20-9 dimethyl 4-(4-(2-chloro-6-fluoroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate 
• 860296-85-1 2-chloro-6-fluoro-4-methoxy-quinoline 

Relevant articles and documents

Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold

Angiogenesis is essential in the growth of solid tumors which need oxygen and nutrients supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in tumor angiogenesis. Sorafenib is an FDA approved cancer therapeutic with activity

4-Aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome sequencing of mutants raised against AQs, identified decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) as the primary target responsible for the antitubercular activity. Mass spectrometry and enzyme kinetic studies indicated that AQs are noncovalent, reversible inhibitors of DprE1 with slow on rates and long residence times of ～100 min on the enzyme. In general, AQs have excellent leadlike properties and good in vitro secondary pharmacology profile. Although the scaffold started off as a single active compound with moderate potency from the whole cell screen, structure-activity relationship optimization of the scaffold led to compounds with potent DprE1 inhibition (IC50 10 nM) along with potent cellular activity (MIC = 60 nM) against Mtb.

THERAPEUTIC AGENTS I

Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.