406207-65-6

Basic information

• Product Name: 2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: BUTTPARK 7\05-91;2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 406207-65-6
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.24
• Mol File: 406207-65-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.01 g/cm³
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE(406207-65-6)
• EPA Substance Registry System: 2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE(406207-65-6)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 406207-65-6(Hazardous Substances Data)

Usage

General Description

2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE is a chemical compound that is also known as "Tolimidone" and "Tolrestat". It is a synthetic compound with a molecular formula of C11H14N2 and a molecular weight of 174.24 g/mol. This chemical is commonly used in the pharmaceutical industry as a potential drug candidate for the treatment of diabetes and diabetic complications. It is known for its inhibitory effects on aldose reductase, an enzyme involved in the development of diabetic neuropathy, retinopathy, and nephropathy. Research studies have shown that 2-TERT-BUTYL-IMIDAZO[1,2-A]PYRIDINE has the potential to reduce the accumulation of sorbitol in the body and prevent diabetic complications, making it a promising candidate for the development of new treatments for diabetes.

InChI:InChI=1/C11H14N2/c1-11(2,3)9-8-13-7-5-4-6-10(13)12-9/h4-8H,1-3H3

Upstream product

• 504-29-0 2-aminopyridine 
• 5469-26-1 1-Bromopinacolon 
• 75-97-8 3,3-dimethyl-butan-2-one 

Downstream Products

• 1467063-90-6 2-tert-butyl-3-(3,5-dimethylphenyl)imidazo[1,2-a]pyridine 
• 1467063-91-7 2-tert-butyl-3-(4-chlorophenyl)imidazo[1,2-a]pyridine 
• 1467063-92-8 2-tert-butyl-3-(3-chlorophenyl)imidazo[1,2-a]pyridine 
• 1467063-93-9 2-tert-butyl-3-(2-chlorophenyl)imidazo[1,2-a]pyridine 
• 1467063-94-0 2-tert-butyl-3-(4-ethylphenyl)imidazo[1,2-a]pyridine 
• 1609583-44-9 2-(tert-butyl)-3-(phenylthio)imidazo[1,2-a]pyridine 
• 904813-48-5 3-bromo-2-(tert-butyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Electrochemical Oxidative C3 Acyloxylation of Imidazo[1,2- a]pyridines with Hydrogen Evolution

The C3-functionalized imidazo[1,2-a]pyridines are versatile nitrogen-fused heterocycles; however, the methods for the C3 acyloxylation of imidazo[1,2-a]pyridines have never been reported. Herein we demonstrate the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines for the first time. Notably, by using electricity, the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines was carried out under mild conditions. Moreover, in addition to aromatic carboxylic acids, alkyl carboxylic acids were also competent substrates.

Formation of Methylene Linkage for N-Heterocycles: Sequential C-H and C-O Bond Functionalization of Methanol with Cosolvent Water

An iron-catalyzed methylene forming strategy is disclosed through sequential C-H and C-O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo[1,2-a]pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.

Copper(I) iodide-catalysed aerobic oxidative synthesis of imidazo [1,2-α]pyridines from 2-aminopyridines and methyl ketones

We report here an operationally simple copper-catalysed synthesis of imidazo [1,2-α]pyridines through C-H activation with oxidative linkage of two C-N bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo [1,2-α]pyridines including the antiulcer drug zolimidine from inexpensive and readily available 2-aminopyridines and methyl ketones with broad range of functional group tolerance.