406234-25-1

Basic information

• Product Name: methyl 4-(6-methoxypyridin-3-yl)benzoate
• Synonyms: methyl 4-(6-methoxypyridin-3-yl)benzoate
• CAS NO: 406234-25-1
• Molecular Weight: 243.262
• Mol File: 406234-25-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-(6-methoxypyridin-3-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(6-methoxypyridin-3-yl)benzoate(406234-25-1)
• EPA Substance Registry System: methyl 4-(6-methoxypyridin-3-yl)benzoate(406234-25-1)

Safety Data

• Hazardous Substances Data: 406234-25-1(Hazardous Substances Data)

Upstream product

• 13472-85-0 2-methoxy-5-bromopyridine 
• 16567-18-3 8-bromoquinoline 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1126-46-1 Methyl 4-chlorobenzoate 

Relevant articles and documents

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides

Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon-carbon bonds in the pharmaceutical industry, the Suzuki-Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfinates, a cross-coupling process of unrivalled scope and utility is realized. The corresponding 3-And 4-substituted pyridine variants are also efficient coupling partners. In addition, we apply these sulfinates in a library format to the preparation of medicinally relevant derivatives of the drugs varenicline (Chantix) and mepyramine (Anthisan).

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.