406234-48-8

Basic information

• Product Name: methyl 4-(quinolin-8-yl)benzoate
• Synonyms: methyl 4-(quinolin-8-yl)benzoate
• CAS NO: 406234-48-8
• Molecular Weight: 263.296
• Mol File: 406234-48-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 4-(quinolin-8-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(quinolin-8-yl)benzoate(406234-48-8)
• EPA Substance Registry System: methyl 4-(quinolin-8-yl)benzoate(406234-48-8)

Safety Data

• Hazardous Substances Data: 406234-48-8(Hazardous Substances Data)

Upstream product

• 16567-18-3 8-bromoquinoline 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 148-24-3 8-quinolinol 
• 905966-40-7 methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 
• 916314-51-7 quinolin-8-yl methanesulfonate 

Relevant articles and documents

Bathocuproine-Enabled Nickel-Catalyzed Selective Ullmann Cross-Coupling of Two sp 2-Hybridized Organohalides

Cross-coupling reactions are essential for the synthesis of complex organic molecules. Here, we report a nickel-catalyzed Ullmann cross-coupling of two sp 2-hybridized organohalides, featuring high cross-selectivity when the two coupling partners are used in a 1:1 ratio. The high chemoselectivity is governed by the bathocuproine ligand. Moreover, the mild reductive reaction conditions allow that a wide range of functional groups are compatible in this Ullmann cross-coupling.

Trans -chloro(1-naphthyl)bis(triphenylphosphine)nickel(II)/PCy3 catalyzed cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates at room temperature

trans-Chloro(1-naphthyl)bis(triphenylphosphine)nickel(II) complex/PCy 3 system has been successfully applied as catalyst for the Suzuki-Miyaura cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates in THF at room temperature. This cross-coupling reaction tolerates various functional groups, including keto, imino, ester, ether, and cyano. Together with the nickel-catalyzed, one-pot, two-step neopentylglycolborylation, this bench stable and inexpensive Ni(II)-based catalyst can be utilized as an alternative to Ni(COD) 2/PCy3 to provide an inexpensive, robust, and convenient synthesis of biaryl and heterobiaryl compounds.

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.