40652-47-9

Basic information

• Product Name: AKOS BC-0854
• Synonyms: CHEMBRDG-BB 4013934;AKOS BC-0854;N-(1,1-DIMETHYL-3-OXOBUTYL)ACETAMIDE;N-(1,1-dimethyl-3-oxobutyl)acetamide(SALTDATA: FREE)
• CAS NO: 40652-47-9
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.21
• Mol File: 40652-47-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 308.753°C at 760 mmHg
• Flash Point: 135.168°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.435
• CAS DataBase Reference: AKOS BC-0854(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BC-0854(40652-47-9)
• EPA Substance Registry System: AKOS BC-0854(40652-47-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 40652-47-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H15NO2/c1-6(10)5-8(3,4)9-7(2)11/h5H2,1-4H3,(H,9,11)

Upstream product

• 108-24-7 acetic anhydride 
• 625-04-7 4-amino-4-methylpentan-2-one 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 7664-93-9 sulfuric acid 
• 75-05-8 acetonitrile 
• 625-03-6 4-amino-4-methylpentan-2-one oxalate 
• 127-09-3 sodium acetate 
• 2261-02-1 acetylium tetrafluoroborate 
• 115-11-7 isobutene 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 108-10-1 4-methyl-2-pentanone 
• 40652-46-8 N-(3-Acetylamino-1,1-dimethyl-but-3-enyl)-acetamide 
• 67-64-1 acetone 

Downstream Products

• 91875-52-4 N-(3-hydroxy-1,1-dimethyl-butyl)-acetamide 
• 22675-72-5 4-ethylamino-4-methyl-pentan-2-ol 
• 4404-98-2 4-amino-4-methylpentan-2-ol 

Relevant articles and documents

Identification of diacetonamine from soybean curd residue as a sporulation-inducing factor toward Bacillus spp.

Under bioassay-guided investigation, a sporulation-inducing factor (SIF) toward Bacillus spp. was searched for in methanol (MeOH) extracts of soybean curd residues, and diacetonamine (1) was identified as the active compound. SIF was first isolated as a monoacetylated derivative (2, 4.1?mg from 655?g soybean curd residues), and its chemical structure was elucidated by field desorption mass spectrometry, electron ionization mass spectrometry, and nuclear magnetic resonance (NMR) analyses. After 48-h incubation, 40?μM diacetonamine hydrochloride (1b) exhibited sporulation-inducing activity with 35% sporulation frequency toward a Bacillus amyloliquefaciens wild-type strain (AHU 2170), whereas 40?μM diacetone acrylamide (3) showed 99% sporulation induction, which was much higher than that of 1b. Although Bacillus megaterium NBRC 15308 was sporulated by the treatment with 400?μM 1b with 36 and 70% sporulation frequency after 72- and 96-h incubation respectively, 3 at the same concentration showed only 2% sporulation after 72-h incubation. Hence, diacetonamine (1) was characterized as a genuine SIF from soybean curd residues, but it was uncertain whether 1 is a natural product or an artifact. Spores of B. amyloliquefaciens induced by 1b survived after treatment with heating at 95?°C for 10?min, also suggesting that 1 is genuine SIF in soybean curd residue. As sporulation induction is likely linked to activation of antibiotic production in some spore-forming Firmicutes bacteria, compound 1 would be a possible chemical tool to develop an effective fermentation technology in Bacillus species.

ACYLATION OF OLEFINS WITH ACETYL FLUOROBORATE IN THE PRESENCE OF ACETONITRILE

The acylation of styrene, isobutylene, vinylcyclopropane, and methylenecyclobutane with acetyl fluoroborate in the presence of acetonitrile takes place as the conjugate addition of the acetyl cation and acetonitrile to the double bond of the olefin.Depending on the temperature, it leads to the corresponding N-acetylamino ketones or substituted 6-fluoro-5,6-dihydro-1,3-oxazines.