40664-73-1

Basic information

• Product Name: Acetamide, N-(4-acetyl-2-methylphenyl)-
• Synonyms: 4'-acetylamino-3'-methyl-acetophenone;6-Acetamino-3-acetyl-toluol;N-(4-ethanoyl-2-methyl-phenyl)ethanamide;4-Acetamino-3-methyl-acetophenon;Acetamide,N-(4-acetyl-2-methylphenyl);acetic acid-(4-acetyl-2-methyl-anilide);4'-acetyl-2'-methylacetanilide;Essigsaeure-(4-acetyl-2-methyl-anilid)
• CAS NO: 40664-73-1
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 40664-73-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 379.7±30.0 °C(Predicted)
• Density: 1.122±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Acetamide, N-(4-acetyl-2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-acetyl-2-methylphenyl)-(40664-73-1)
• EPA Substance Registry System: Acetamide, N-(4-acetyl-2-methylphenyl)-(40664-73-1)

Safety Data

• Hazardous Substances Data: 40664-73-1(Hazardous Substances Data)

Upstream product

• 117324-09-1 N-(4-iodo-2-methylphenyl)acetamide 
• 431-03-8 dimethylglyoxal 
• 95-53-4 o-toluidine 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 108-24-7 acetic anhydride 
• 43230-11-1 4'-amino-3'-methyl-acetophenone 

Downstream Products

• 37074-40-1 1-(4-bromo-3-methylphenyl)ethan-1-one 
• 43230-11-1 4'-amino-3'-methyl-acetophenone 
• 97760-92-4 3'-acetoxymethyl-4'-acetylamino-2-(N-benzyl-tert.-butylamino)-acetophenone 
• 97760-93-5 4'-amino-2-(N-benzyl-tert.-butylamino)-3'-hydroxymethyl-acetophenone 
• 97760-83-3 3'-acetoxymethyl-4'-acetylamino-acetophenone 
• 97760-81-1 4'-amino-3'-chloro-5'-methyl-acetophenone 
• 55413-89-3 4'-acetylamino-3'-diethylaminomethyl-acetophenone 
• 97776-08-4 4'-amino-3'-diethylaminomethyl-acetophenone 
• 97760-86-6 4'-amino-3'-bromo-5'-diethylaminomethyl-acetophenone 
• 54238-54-9 1-(4-amino-3-hydroxymethyl-phenyl)-2-tert.-butylamino-ethanol 
• 56340-03-5 N-[4-(2-tert-Butylamino-1-hydroxy-ethyl)-2-diethylaminomethyl-phenyl]-acetamide 
• 56340-99-9 1-(4-Amino-3-bromo-5-diethylaminomethyl-phenyl)-2-tert-butylamino-ethanol 
• 56341-00-5 1-(4-Amino-3-bromo-5-diethylaminomethyl-phenyl)-2-tert-butylamino-ethanone 
• 56340-02-4 1-(4-Amino-3-diethylaminomethyl-phenyl)-2-tert-butylamino-ethanol 

Relevant articles and documents

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.

METHOD OF FRIEDEL-CRAFTS ACYLATION OF ANILIDES

An anilide is reacted with an acylating agent by using as a catalyst a tri (perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.