40665-94-9 Usage
Description
Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds, particularly in the production of (+)-cloprostenol and α-pentanorbenzo analogs of prostaglandins. These prostaglandins are essential in the treatment of various medical conditions, highlighting the significance of this intermediate in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate is used as a key intermediate for the synthesis of [application type] (+)-cloprostenol and α-pentanorbenzo analogs of prostaglandins for [application reason] their potential therapeutic applications in treating various medical conditions.
Dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate plays a vital role in the development of new drugs and therapies, contributing to the advancement of healthcare and improving the quality of life for patients suffering from different health issues. Its use in the pharmaceutical industry underscores its importance in the development of innovative and effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 40665-94-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,6 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 40665-94:
(7*4)+(6*0)+(5*6)+(4*6)+(3*5)+(2*9)+(1*4)=119
119 % 10 = 9
So 40665-94-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H14ClO5P/c1-15-18(14,16-2)8-10(13)7-17-11-5-3-4-9(12)6-11/h3-6H,7-8H2,1-2H3
40665-94-9Relevant articles and documents
The optically pure sodium alcoholate dextrorotary chlorine forefront of the method for the preparation of
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, (2018/02/04)
The invention relates to a preparation method of optically pure dextro cloprostenol sodium. The method comprises the following steps: using the combination of ketonic acid and S-phenylethylamine resolving agent, and carrying out chiral resolution to obtain S-propenylphosphonate with the structural formula of R-ketonic acid; then separating to obtain R-chlorone and preparing to obtain R-cloprostenol sodium. The preparation method has the benefits that the optically pure dextro cloprostenol sodium in the invention is called D-cloprostenol sodium for short, the using amount only needs one third of cloprostenol sodium being a racemic modification in current market, and the pesticide effect is obviously better than cloprostenol sodium with three times of using amount.
Preparation of cloprostenol and fluprostenol analogs for treating glaucoma and ocular hypertension.
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, (2008/06/13)
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PROSTANOIDS. XXX. SYNTHESIS OF THE ANALOGS OF 11-DEOXYPROSTA-GLANDINS E AND F
Tolstikov, G. A.,Miftakhov, M. S.,Adler, M. E.,Platonov, V. E.,Sagitdinova, Kh. F.,Khalilov, L. M.
, p. 100 - 107 (2007/10/02)
A practical approach to 11-deoxyprostaglandins is developed on the basis of the chemo- and stereoselective reduction of the readily obtainable methyl 9,15-diketo-16-aryloxyprostenoates.