406681-09-2

Basic information

• Product Name: (R)-METHYL BOPHOZ(TM)
• Synonyms: (S)-N-Diphenylphosphino-N-methyl-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine Methyl BoPhoz;(S)-N-Diphenylphosphino-N-methyl-(R)-2-(diphenylphosphino)ferrocenylüethylamine, (S)-Methyl BoPhoz;(S)-N-Methyl-N-diphenylphosphino-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine;Methyl-BoPhoz, (1S)-1-(Diphenylphosphino)-2-[(1S)-1-[(diphenylphosphino)methylamino]ethyl]ferrocene;(S)-N-Diphenylphosphino-N-methyl-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine, (S)-Methyl BoPhoz^t;(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[(diphenylphosphino)methylamino]ethyl]ferrocene;(S)-1-[(R)-2-Diphenylphosphinoferrocenyl](N-Methyl)(N-diphenylphosphino)ethylaMine (S)-Me-Bophoz;Ferrocene,1-(diphenylphosphino)-2-[(1S)-1-[(diphenylphosphino)MethylaMino]ethyl]-, (1S)-
• CAS NO: 406681-09-2
• Molecular Formula: C37H35FeNP2 10*
• Molecular Weight: 611.47
• Mol File: 406681-09-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 80-82°C
• Appearance: yellow/solid
• CAS DataBase Reference: (R)-METHYL BOPHOZ(TM)(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-METHYL BOPHOZ(TM)(406681-09-2)
• EPA Substance Registry System: (R)-METHYL BOPHOZ(TM)(406681-09-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 406681-09-2(Hazardous Substances Data)

Usage

Description

(R)-METHYL BOPHOZ(TM) is a yellow to orange amorphous solid that serves as an efficient ligand for various chemical reactions, particularly in the field of asymmetric hydrogenation. It is a valuable compound for synthesizing specific enantiomers of amino acids and other chiral molecules, which are essential in pharmaceuticals and other industries.

Uses

Used in Pharmaceutical Industry:
(R)-METHYL BOPHOZ(TM) is used as an efficient ligand for asymmetric hydrogenation reactions to synthesize a single enantiomer of cyclopropylalanine. This is crucial in the development of pharmaceuticals, as the specific enantiomer can have desired biological activities and reduced side effects.
Used in Chemical Synthesis:
(R)-METHYL BOPHOZ(TM) is used as a catalyst in the preparation of chiral phenylalanine derivatives from α-amido cinnamic acids (or esters). This application is vital for the production of various chiral compounds that are essential in the pharmaceutical, agrochemical, and fragrance industries.
Used in Research and Development:
(R)-METHYL BOPHOZ(TM) is employed in research and development for the synthesis of novel chiral compounds and the optimization of asymmetric hydrogenation reactions. Its use in this context helps to advance the understanding of enantioselective catalysis and the development of new methodologies for the production of enantiomerically pure compounds.

Reaction

Ligand used in the rhodium-catalyzed, asymmetric hydrogenation of β-amido-vinylphosphonates. Ligand used in the rhodium or iridium-catalyzed asymmetric hydrogenation of α,β-unsaturated esters.