406681-12-7Relevant articles and documents
Diastereomer-differentiating hydrolysis of 1,3-diol-acetonides: A simplified procedure for the separation of syn-and anti-1,3-diols
Bode, Silke E.,Muller, Michael,Wolberg, Michael
, p. 619 - 621 (2002)
(formula presented) A new method to facilitate the separation of diastereomeric syn- and anti-1,3-diols is described. The method relies on the different hydrolysis rates of the corresponding diastereomeric acetonides. Treatment of a dichloromethane solution of syn- and anti-1,3-diol-acetonide with a catalytic amount of diluted aqueous hydrochloric acid leads to the selective cleavage of the anti diastereomer. The resulting anti-1,3-diol can be easily separated from the unchanged syn-1,3-diol-acetonide.
