40738-83-8 Usage
Description
5-IODO-1,3-DIMETHYLURACIL is an organic compound with the molecular formula C6H7I2N2O2. It is derived from uracil, a pyrimidine base found in RNA, and features a 5-iodo substitution along with two methyl groups at the 1 and 3 positions. 5-IODO-1,3-DIMETHYLURACIL has been studied for its potential applications in various fields, particularly in the synthesis of certain pharmaceutical compounds.
Uses
Used in Pharmaceutical Synthesis:
5-IODO-1,3-DIMETHYLURACIL is used as a key intermediate in the synthesis of N-[2-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)thio]-4-oxo[1]benzothieno[3,2-d]pyrimidin-3(4H)yl]methanesulfonamide, a complex molecule with potential applications in the pharmaceutical industry.
Used in Cancer Research:
The effect of 5-IODO-1,3-DIMETHYLURACIL on the incorporation of [125I] 5-iodo-2′-deoxyuridine [125I radiolabelled IdUrd] in DNA of cancer cells has been studied. This research could potentially lead to the development of new therapeutic strategies for cancer treatment.
Used in Chemical Synthesis:
5-IODO-1,3-DIMETHYLURACIL can be synthesized from aromatic organomercurials, such as 5-(acetoxymercurio)-1,3-dimethyluracil or 5,5′-mercuriobis(1,3-dimethyluracil). This synthesis method is important for the production of 5-IODO-1,3-DIMETHYLURACIL and its subsequent use in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 40738-83-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,7,3 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 40738-83:
(7*4)+(6*0)+(5*7)+(4*3)+(3*8)+(2*8)+(1*3)=118
118 % 10 = 8
So 40738-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H7IN2O2/c1-8-3-4(7)5(10)9(2)6(8)11/h3H,1-2H3
40738-83-8Relevant articles and documents
Atom-economical transformation of diaryliodonium salts: Tandem C-H and N-H arylation of indoles
Modha, Sachin G.,Greaney, Michael F.
supporting information, p. 1416 - 1419 (2015/02/19)
Arylation using diaryliodonium salts generates one equivalent of an iodoarene as a side-product, a significant waste of atom economy. Here, we show that diaryliodoniums can undergo Cu-catalyzed tandem C-H/N-H arylation, producing novel indoles that incorporate both aryl groups from the reagent.
