407619-06-1

Basic information

• Product Name: N-[(benzoylamino)carbonyl]-4-cyano-N-methyl-3-(2,4,6-trimethoxyphenyl)isoxazole-5-carboxamide
• Synonyms: N-[(benzoylamino)carbonyl]-4-cyano-N-methyl-3-(2,4,6-trimethoxyphenyl)isoxazole-5-carboxamide
• CAS NO: 407619-06-1
• Molecular Weight: 464.434
• Mol File: 407619-06-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(benzoylamino)carbonyl]-4-cyano-N-methyl-3-(2,4,6-trimethoxyphenyl)isoxazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(benzoylamino)carbonyl]-4-cyano-N-methyl-3-(2,4,6-trimethoxyphenyl)isoxazole-5-carboxamide(407619-06-1)
• EPA Substance Registry System: N-[(benzoylamino)carbonyl]-4-cyano-N-methyl-3-(2,4,6-trimethoxyphenyl)isoxazole-5-carboxamide(407619-06-1)

Safety Data

• Hazardous Substances Data: 407619-06-1(Hazardous Substances Data)

Upstream product

• 2904-59-8 2,4,6-trimethoxybenzonitrile N-oxide 
• 329358-19-2 (5Z)-1-benzoyl-5-(cyanomethylidene)-3-methylimidazolidine-2,4-dione 
• 407618-99-9 (2Z)-2-(1-methyl-2,5-dioxoimidazolidin-4-ylidene)acetonitrile 
• 88801-18-7 (5Z)-5-[(dimethilamino)methylidene]-3-methylimidazolidine-2,4-dione 

Downstream Products

• 3201-53-4 N-[(methylamino)carbonyl]benzamide 

Relevant articles and documents

1,3-Dipolar cycloadditions to (5Z)-1-Acyl-5-(cyanomethylidene)-imidazolidine-2,4-diones: Synthesis and transformations of spirohydantoin derivatives

Cycloadditions of various 1,3-dipoles to (5Z)-1-acyl-5-(cyanomethylidene)-3-methylimidazolidine-2,4-diones 8 or 9, prepared in 3 steps from hydantoin (1) (Schemes 1 and 2), were studied. In all cases, reactions proceeded regio- and stereoselectively. The type of product depended on the 1,3-dipole and/or dipolarophile employed as well as on reaction conditions. Thus, with stable dipoles under neutral conditions, spirohydantoin derivatives 12-16 were obtained (Scheme 2), while under basic or acidic conditions, pyrazole- or isoxazole-5-carboxamides 18 and 23-26 and carboxylate 27 were formed via aromatization of the newly formed dihydroazole ring, followed by the simultaneous cleavage of the hydantoin ring (Schemes 3-5).