40778-79-8

Basic information

• Product Name: 3-[((R)-carboxy-phenyl-methyl)-amino]-but-2-enoic acid methyl ester
• Synonyms: 3-[((R)-carboxy-phenyl-methyl)-amino]-but-2-enoic acid methyl ester
• CAS NO: 40778-79-8
• Molecular Weight: 249.266
• Mol File: 40778-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[((R)-carboxy-phenyl-methyl)-amino]-but-2-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[((R)-carboxy-phenyl-methyl)-amino]-but-2-enoic acid methyl ester(40778-79-8)
• EPA Substance Registry System: 3-[((R)-carboxy-phenyl-methyl)-amino]-but-2-enoic acid methyl ester(40778-79-8)

Safety Data

• Hazardous Substances Data: 40778-79-8(Hazardous Substances Data)

Upstream product

• 875-74-1 (R)-phenylglycine 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 124831-39-6 (6R,7S)-3-Chloro-7-[(R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 76470-66-1 loracarbef 
• 53116-67-9 (6R)-3-methoxy-7t-[(R)-2-(2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

Preparation method of ampicillin impurity I

The invention discloses a preparation method of an ampicillin impurity I. The preparation method comprises the following steps: heating D-phenylglycine and strong base for reacting to obtain salt, performing a condensation reaction with a keto ester reagent, cooling and filtering to obtain a Dane salt intermediate IV; enabling the Dane salt intermediate IV to react with acyl chloride in an aproticsolvent by adopting organic base as a catalyst, so as to obtain acid anhydride V; enabling the acid anhydride V to react with an intermediate VI, and filtering to obtain solid which is the ampicillinimpurity I. According to the preparation method of the ampicillin impurity I, a synthesis path is relatively simple and quick, reaction conditions are relatively mild, and the raw materials and the reagent are cheap and easily available. Moreover, compared with preparation of general impurities using a column chromatographic separation technology, the method can directly obtain many target products through crystallization.