40784-94-9Relevant articles and documents
Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors
Kerdesky, Francis A.J.,Brooks, Clint D.W.,Hulkower, Keren I.,Bouska, Jennifer B.,Bell, Randy L.
, p. 393 - 396 (1997)
Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.