4079-51-0

Basic information

• Product Name: Ethanone, 1-(3-bromophenyl)-2-hydroxy-
• CAS NO: 4079-51-0
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Mol File: 4079-51-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3-bromophenyl)-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-bromophenyl)-2-hydroxy-(4079-51-0)
• EPA Substance Registry System: Ethanone, 1-(3-bromophenyl)-2-hydroxy-(4079-51-0)

Safety Data

• Hazardous Substances Data: 4079-51-0(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(3-bromophenyl)-2-hydroxy-, also known as 3-bromo-1-(2-hydroxyphenyl)acetone, is a chemical compound that belongs to the class of ketones. It is characterized by a molecule consisting of a carbonyl group attached to a phenyl ring with a bromine atom and a hydroxyl group at specific positions. This chemical is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block for more complex molecules. Additionally, it possesses properties that make it useful in the development of drugs and bioactive compounds. However, it is important to handle this chemical with caution as it may pose potential health hazards if not properly managed.

Upstream product

• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 3132-99-8 m-bromobenzoic aldehyde 
• 298-12-4 Glyoxilic acid 
• 67-56-1 methanol 
• 1345694-93-0 α-tosyloxy-m-bromoacetophenone 
• 67-64-1 acetone 
• 18523-22-3 2,3'-dibromoacetophenone 
• 2039-86-3 3-bromostyrene 
• 842155-19-5 α-acetoxy-3-bromoacetophenone 
• 50-00-0 formaldehyd 

Downstream Products

• 1218-80-0 6-bromoflavone 
• 1610616-79-9 4-(3-bromophenyl)-4-vinyl-1,3-dioxolan-2-one 
• 55222-57-6 3-<2-(3-bromophenyl)-2-oxoethyl>-1(3H)-isobenzofuranone 

Relevant articles and documents

One-Pot Enzymatic-Chemical Cascade Route for Synthesizing Aromatic α-Hydroxy Ketones

2-Hydroxyacetophenone (2-HAP) is an important building block for the production of a series of natural products and pharmaceuticals; however, there is no safe, efficient, and economical method for 2-HAP synthesis. Here, a one-pot enzymatic-chemical cascade route was designed for synthesizing 2-HAP based on retrosynthetic analysis. First, a spontaneous proton-transfer reaction was designed using a computational simulation that enabled 2-HAP synthesis from the isomer 2-hydroxy-2-phenylacetaldehyde. A route for 2-hydroxy-2-phenylacetaldehyde synthesis was then constructed by introducing the unnatural substrate glyoxylic acid into a C-C ligation reaction catalyzed by Candida tropicalis pyruvate decarboxylase. Assembly and optimization of this enzymatic-chemical cascade route resulted in a final yield of 92.7%. Furthermore, stereospecific carbonyl reductases were introduced to construct a synthetic application platform that enabled further transformation of 2-HAP into (S)- and (R)-1-phenyl-1,2-ethanediol. This method of cascading spontaneous chemical and enzymatic reactions to synthesize chemicals offers insight into avenues for synthesizing other valuable chemicals.

Palladium-Catalyzed (3+3) Annulation of Allenylethylene Carbonates with Nitrile Oxides

In this paper, we designed and synthesized a new type of cyclic carbonates, allenylethylene carbonates (AECs). With AECs as reactive precursors, we developed palladium-catalyzed (3+3) annulation of AECs with nitrile oxides. Various AECs worked well in this reaction under mild reaction conditions. A variety of 5,6-dihydro-1,4,2-dioxazine derivatives with allenyl quaternary stereocenters can be accessed in a facile manner in high yields (≤98%).

Copper-Catalyzed Enantioselective Construction of Tertiary Propargylic Sulfones

Tertiary propargylic sulfones are of significant importance in organic synthesis and medicinal chemistry, but to date no general asymmetric synthesis approach has been developed. We disclose a versatile copper-catalyzed sulfonylation of propargylic cyclic carbonates using sodium sulfinates that allows the construction of propargylic sulfones featuring elusive quaternary stereocenters. This method provides the first successful example of such an enantioselective propargylic sulfonylation, features high asymmetric induction, wide functional group tolerance, and scalability, and enables attractive product diversification.