408309-32-0

Basic information

• Product Name: 5-ethylbenzene-1,3-diamine
• Synonyms: 5-ethylbenzene-1,3-diamine
• CAS NO: 408309-32-0
• Molecular Weight: 136.197
• Mol File: 408309-32-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-ethylbenzene-1,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethylbenzene-1,3-diamine(408309-32-0)
• EPA Substance Registry System: 5-ethylbenzene-1,3-diamine(408309-32-0)

Safety Data

• Hazardous Substances Data: 408309-32-0(Hazardous Substances Data)

Upstream product

• 33786-92-4 3,5-diaminoacetophenone 
• 18242-39-2 3,5-dinitrobromobenzene 
• 72918-18-4 1,3-dinitro-5-vinylbenzene 

Downstream Products

• 669091-99-0 3-ethyl-5-amino-phenol 

Relevant articles and documents

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790Mmutant with improved pharmacokinetic properties

Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFRT790Minhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFRL858R/T790Mkinase and inhibited the proliferation of H1975?cells with IC50values of 2.0?nM and 40?nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERK in NCI[sbnd]H1975?cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients.