40843-79-6Relevant articles and documents
PROCESS FOR THE PRODUCTION OF ANTIDIABETIC OXAZOLIDINEDIONES
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, (2008/06/13)
The present invention provides a convergent process for the preparation of a family of antidiabetic phenoxy-substituted phenoxybenzyl oxazolidinediones shown as structure I. The compounds are selective PPAR gamma partial agonists (SPPARM's), which are use
5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists
Koyama, Hiroo,Boueres, Julia K.,Han, Wei,Metzger, Edward J.,Bergman, Jeffrey P.,Gratale, Dominick F.,Miller, Daniel J.,Tolman, Richard L.,MacNaul, Karen L.,Berger, Joel P.,Doebber, Thomas W.,Leung, Kwan,Moller, David E.,Heck, James V.,Sahoo, Soumya P.
, p. 1801 - 1804 (2007/10/03)
A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model.
4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
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, (2008/06/13)
Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I STR1 in which R1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R1 and R3 together stand for a --CH=CH--CH=CH-- bridge or--unless at least one of the substituents R2 to R8 stands for hydrogen, or if R9 stands for a radical having at least 2 carbon atoms--for chlorine, R2 and R3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms, R4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R3 and R4 together stand for a --CH=CH--CH=CH-- bridge, R5, R6 and R7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms, R8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl, R9 stands for alkyl of 1 to 10 carbon atoms or phenyl and X stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.