4087-66-5Relevant articles and documents
Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo
Zheng, Judun,Zeng, Qin,Zhang, Ruijing,Xing, Da,Zhang, Tao
, p. 19226 - 19230 (2019)
Here, we report a reversible photoacoustic (PA) probe, BDP-DOH, to image the localized redox state in vivo via monitoring the dynamic changes of the redox couple, superoxide anion (O2a¢-) and glutathione (GSH). The probe features a s
Discovery of N-pyridoyl-Δ2-pyrazolines as Hsp90 inhibitors
Chary, Meghana,Gaddam, Swetha,Kadasi, Sundeep,Pingili, Divya,Pullanagiri, Nikhila,Raghavendra, Nulgumnalli Manjunathaiah,Raj, Shiva,Yerroju, Ravali
, (2019/12/24)
Hsp90, as a key molecular chaperone, plays an important role in modulating the activity of many cell signaling proteins and is an attractive target for anticancer therapeutics. Herein, we report the discovery of N-pyridoyl-Δ2-pyrazoline analogs
Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones
Kumar, Togiti Uday,Thigulla, Yadagiri,Rangan, Krishnan,Bhattacharya, Anupam
supporting information, p. 1283 - 1290 (2019/03/07)
A metal-free approach for the synthesis of 2-acylpyrroles is reported in this paper. Synthesis of the target molecule started from chalcones and was carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target molecules were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion.