40871-01-0

Basic information

• Product Name: methyl 3-propionate
• Synonyms: methyl 3-propionate
• CAS NO: 40871-01-0
• Molecular Weight: 207.272
• Mol File: 40871-01-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: methyl 3-propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-propionate(40871-01-0)
• EPA Substance Registry System: methyl 3-propionate(40871-01-0)

Safety Data

• Hazardous Substances Data: 40871-01-0(Hazardous Substances Data)

Upstream product

• 64-04-0 phenethylamine 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 182559-05-3 2,4-Dioxo-1-phenethyl-piperidine-3-carboxylic acid methyl ester 
• 182559-09-7 1-Phenethyl-4-phenylamino-piperidin-2-one 
• 99539-57-8 1-phenethyl-2,4-dioxopiperidine 
• 403608-64-0 3-{[2-(3-Methyl-butylamino)-acetyl]-phenethyl-amino}-propionic acid methyl ester 
• 38129-46-3 dimethyl β,β'-(2-phenylethylamino)dipropionate 
• 173406-18-3 N-(2-phenylethyl)-3-aminopropionic acid 
• 671204-23-2 3-[(2-Bromo-acetyl)-phenethyl-amino]-propionic acid methyl ester 
• 182558-98-1 N-(2-Methoxycarbonyl-ethyl)-N-phenethyl-malonamic acid methyl ester 
• 18042-77-8 3-[(2-Acetylamino-5-chloro-benzyl)-phenethyl-amino]-propionic acid 

Relevant articles and documents

Iodine-alumina catalyzed Aza- michael addition under solvent free conditions

An efficient aza-Michael addition of amines to a variety of activated olefins was carried out under solvent free conditions using iodine-alumina as a catalyst at room temperature or under microwave irradiation (in case of solid) in high yield. 2009 Bentham Science Publishers Ltd.

N-, α-, and β-substituted 3-aminopropionic acids: Design, syntheses and antiseizure activities

A treatment for epilepsy is proposed based on analogues of 3-aminopropionic acid (β-alanine), a putative neurotransmitter in the central nervous system (CNS). A model three point pharmacophore was proposed based on modelling data obtained from the study of antagonists for both the glial γ-aminobutyric acid (GABA)-uptake site and the glycine co-agonist site of N-methyl-D-aspartate (NMDA) receptor. Three series of 3-aminopropionic acids containing, N-, α-, and β-substituents, were designed and synthesized to probe the position and the size of a lipophilic binding pocket within the proposed pharmacophore. These analogues were tested in vivo for both their antiseizure activities and their neurologic toxicities. Among the fourteen novel 3-aminopropionic acids synthesized, eight were found to have promising antiseizure activity. This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures.

Design and synthesis of potent and selective inhibitors of integrin VLA-4

The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.