40900-01-4

Basic information

• Product Name: 1H-indol-2-yl(4-methoxyphenyl)methanol
• Synonyms: 1H-Indol-2-yl(4-methoxyphenyl)methanol; 1H-indole-2-methanol, alpha-(4-methoxyphenyl)-
• CAS NO: 40900-01-4
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Mol File: 40900-01-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 482.9°C at 760 mmHg
• Flash Point: 245.8°C
• Density: 1.244g/cm³
• Vapor Pressure: 3.9E-10mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 1H-indol-2-yl(4-methoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-indol-2-yl(4-methoxyphenyl)methanol(40900-01-4)
• EPA Substance Registry System: 1H-indol-2-yl(4-methoxyphenyl)methanol(40900-01-4)

Safety Data

• Hazardous Substances Data: 40900-01-4(Hazardous Substances Data)

Usage

Derivative of indole

The compound is derived from the indole structure, which is a common structural motif in organic chemistry and is found in many biologically active compounds.

Methoxyphenyl group attached

The compound has a methoxyphenyl group attached to the 1H-indol-2-yl moiety, which may contribute to its biological activity.

Potential pharmaceutical applications

1H-indol-2-yl(4-methoxyphenyl)methanol has a wide range of potential pharmaceutical applications, including as a pain reliever, anti-inflammatory, anti-tumor, and treatment for neurological disorders.

Analgesic agent

The compound may be used as an analgesic agent, which can help to relieve pain.

Upstream product

• 126754-48-1 <1-<(N,N-dimethylamino)methyl>indol-2-yl>(p-methoxyphenyl)methanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 19005-93-7 1H-indol-2-ylcarboxaldehyde 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 120-72-9 indole 
• 5379-79-3 N-(dimethylaminomethyl)indole 

Relevant articles and documents

Substrate-Controlled Regioselective Arylations of 2-Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3′-Bisindole Derivatives

A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been established, which efficiently afforded bis(indolyl)methane and 3,3′-bisindole derivatives in high yields and with a broad substrate scope (up to 98% yield, 36 examples). This approach will not only provide an important strategy for the diversified synthesis of bis(indolyl)methane and 3,3′-bisindole derivatives but also serve as a good example for substrate-controlled regioselective reactions.

CARBON DIOXIDE: A REAGENT FOR THE PROTECTION OF NUCLEOPHILIC CENTRES AND THE SIMULTANEOUS ACTIVATION OF ALTERNATIVE LOCATIONS TO ELECTROPHILIC ATTACK. PART I. A NEW SYNTHETIC METHOD FOR THE 2-SUBSTITUTION OF 1-UNSUBSTITUTED INDOLES.

Indole was converted into several 2-substituted derivatives by using carbon dioxide both for N-protection and to give an intermediate carbanion stabilizing group. t-Butyllithium was used as a lithiating agent at the alpha-carbon atom of the indole enamino group.The resulting 2-substituted indole-1-carboxylic acids underwent smooth thermal decarboxylation under mild conditions.Alternatively, with longer reaction times the protecting group is lost during the reaction.