40929-48-4

Basic information

• Product Name: 5-Pyrimidinecarbonyl chloride (7CI,9CI)
• Synonyms: 5-Pyrimidinecarbonyl chloride (7CI,9CI);5-Pyrimidinecarbonyl chloride
• CAS NO: 40929-48-4
• Molecular Formula: C₅H₃ClN₂O
• Molecular Weight: 142.54312
• Product Categories: PYRIMIDINE
• Mol File: 40929-48-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 230.8°C at 760 mmHg
• Flash Point: 93.4°C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 0.0646mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 5-Pyrimidinecarbonyl chloride (7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonyl chloride (7CI,9CI)(40929-48-4)
• EPA Substance Registry System: 5-Pyrimidinecarbonyl chloride (7CI,9CI)(40929-48-4)

Safety Data

• Hazardous Substances Data: 40929-48-4(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarbonyl chloride is a chemical compound with the molecular formula C5H2ClN3O. It is a reactive compound that is used as a carbonylating agent in organic synthesis. It is most commonly used in the production of pharmaceuticals and agrochemicals. 5-Pyrimidinecarbonyl chloride is a potent and highly reactive electrophile which can be used to introduce carbonyl groups into a wide range of organic molecules. 5-Pyrimidinecarbonyl chloride (7CI,9CI) finds applications in the manufacturing of various drugs and organic compounds due to its reactivity and versatile nature. It is important to handle this compound with caution due to its reactivity and potential hazards.

InChI:InChI=1/C5H3ClN2O/c6-5(9)4-1-7-3-8-2-4/h1-3H

Upstream product

• 4595-61-3 pyrimidine-5-carboxylic acid 

Downstream Products

• 98405-54-0 N,N-dimethyl-5-pyrimidinecarboxamide 
• 40929-49-5 pyrimidine-5-carboxamide 
• 1361187-90-7 5-{4-[1-(5-pyrimidin-5-yl-[1,2,4]oxadiazol-3-yl)cyclobutyl]phenyl}pyrimidin-2-ylamine 
• 1361189-90-3 5-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrimidine 
• 133510-27-7 3-phenyl-1-(pyrimidin-5-yl)prop-2-yn-1-one 
• 1254973-35-7 C₁₅H₁₄N₂O₅ 
• 861905-60-4 (4-bromo-2-fluorophenyl)(5-pyrimidinyl)methanone 

Relevant articles and documents

N-(indol-5-yl) aromatic heterocyclic amide compound and preparation method and application thereof

The invention belongs to the field of medicines, and relates to an N-(indole-5-yl) aromatic heterocyclic amide compound and a preparation method and application thereof. The structural general formula of the N-(indol-5-yl) aromatic heterocyclic amide compound is shown in the specification. A pharmaceutical composition comprises the N-(indol-5-yl) aromatic heterocyclic amide compound, a pharmaceutically acceptable salt, a hydrate or a solvate of the N-(indol-5-yl) aromatic heterocyclic amide compound and a pharmaceutically acceptable carrier of the N-(indol-5-yl) aromatic heterocyclic amide compound. The invention further discloses application of the N-(indol-5-yl) aromatic heterocyclic amide compound or the pharmaceutically acceptable salt, hydrate or solvate thereof or the pharmaceutical composition in preparation of anti-hyperuricemia and anti-gout drugs. Tests prove that the compound shows a good effect in an in-vitro xanthine oxidase inhibitory activity test. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

Synthesis of N-trifluoromethyl amides from carboxylic acids

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.

Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma

We previously demonstrated that some N-biphenylanilides caused cell-cycle arrest at G2/M transition in breast cancer cells. Among them we choose three derivatives, namely PTA34, PTA73 and RS35 for experimentation in solid tumor cell lines, classical Hodgkin Lymphoma (cHL) cell lines and bona fide normal cell lines. Almost all tumor cells were sensitive to compounds in the nanomolar range whereas, they were not cytotoxic to normal ones. Interestingly the compounds caused a strong G2/M phase arrest in cHL cell lines, thus, here we investigated whether they affected the integrity of microtubules in such cells. We found that they induced a long prometaphase arrest, followed by induction of apoptosis which involved mitochondria. PTA73 and RS35 induced the mitotic arrest through the fragmentation of microtubules which prevented the kinethocore-mitotic spindle interaction and the exit from mitosis. PTA34 is instead a tubulin-targeting agent because it inhibited the tubulin polymerization as vinblastine. As such, PTA34 maintained the Cyclin B1-CDK1 regulatory complex activated during the G2/M arrest while inducing the inactivation of Bcl-2 through phosphorylation in Ser70, the degradation of Mcl-1 and a strong activation of BIML and BIMS proapoptotic isoforms. In addition PTA34 exerted an antiangiogenic effect by suppressing microvascular formation.